癌宁对人胃腺癌细胞SGC-7901形态学的改变及蛋白合成的抑制  

Morphological Changes and Inhibiting Effect on Human Gastric Cancer Cell SGC-7901 Caused by Aining

作　　者：苏勉诚 戴梅 吕晓英[3] 李红坤[4] 刘继林[4] 

机构地区：[1]广东省珠海市国家中药现代化工程技术研究中心,519020 [2]重庆市沙坪坝区中医院,200040 [3]四川大学公卫学院,成都610041 [4]成都中医药大学,610075

出　　处：《中药材》2002年第5期339-342,共4页Journal of Chinese Medicinal Materials

摘　　要：目的:探索癌宁对人胃癌细胞的抑制作用。方法:采用形态学、MTT法,对中药复方癌宁和顺铂抑制胃癌细胞的增殖进行深入研究。结果:经癌宁及顺铂处理后的细胞出现凋亡形态学改变;癌宁在1g/L浓度对胃癌细胞的抑制率是51％,与25mg/L顺铂对胃癌细胞的抑制率53％间无显著差异(P>0.05),两者均与空白对照组有显著差异(P<0.01)。结论:癌宁及顺铂对人胃癌细胞的增殖活性具有抑制作用,中药复方癌宁可望成为一种有前途的抗癌新药。Objective: To investigate the inhibiting effect of Aining on the human gastric cancer cells. Methods: Morphological and MTT methods were adopted to explore the inhibiting effect of Aining and cisplatin (DDP) on the proliferation of SGC-7901 cancer cell. Results: Apoptotic morphological changes were seen after the cells cultured with Aining and DDP; inhibiting rate of 1 g/L Aining group was 51%, which had no significant differences with the inhibiting rate 53% of the 25 mg/L DDP group. But both the Aining and the DDP groups were significantly different from the blank group (P< 0.01). Conclusion: Not only DDP but also Aining could inhibit the proliferation activity of the human gastric cancer cells, and the traditional Chinese medicine compound prescription Aining is very likely to become a new medicine which is utilized to inhibit cancer.

关 键 词：胃腺癌 蛋白合成 癌宁 MTT法 形态学 胃癌细胞 抑瘤作用 

分 类 号：R286.91[医药卫生—中药学] R285.5[医药卫生—中医学]