10-羟基-2-癸烯酸治疗实验性高脂血症大鼠的药理研究  

The Research of 10-Hydroxy-2-Decenoic Acid on Experiment Hyperlipoidemic Rat

作　　者：许东晖[1] 梅雪婷[1] 许实波[1] 

机构地区：[1]中山大学药学系,广州510275

出　　处：《中药材》2002年第5期346-347,共2页Journal of Chinese Medicinal Materials

基　　金：国家863资助课题(2001AA6204080);广东省重点攻关项目(99B04902G)

摘　　要：目的:本实验研究蜂王酸即10-羟基-2-癸烯酸(10-Hydroxy-2-Decenoic Acid,10-HDA)对治疗实验性高脂血症大鼠的药理作用。方法:通过喂养高脂食物建立高脂血动物模型,测定10-HAD对高脂血动物预防给药及治疗给药的作用。结果:10-HAD具有明显降低实验性高脂血症大鼠血液中甘油三酯(TG)、总胆固醇(TC)、β-脂蛋白含量,同时升高高密度脂蛋白(HDL)含量,说明10-HDA对高脂血症具有良好的治疗作用。结论:10-HAD是蜂王浆治疗高脂血症中的功能因子。Objective: To study the pharmacological effect of 10-hydroxy-2-decenoic acid( 10-HDA) in experiment hyperlipoidemic rat. Methods: Preventive and therapeutic effects of 10-HDA were tested on hyperlioidemic rat model induced by high fat food. Results: 10-HDA could reduce the content of TC, TG and β-lioprotein, raise the content of HDL, which showed 10-HDA had preventive and therapeutic effects on hyperlipoidemic rat. Conclusion: 10-HDA was functional factor of preventive and therapeutic effects of royal jelly on hyperlipoidemia.

关 键 词：10-羟基-2-癸烯酸 高脂血症 高胆固醇症 药理学 蜂蜜 蜂王浆 

分 类 号：R259.872[医药卫生—中西医结合] R285[医药卫生—中医内科学]