吗啡类毒品中毒死者主要脏器内吗啡分布的研究  

An immunohistochemical study on the distribution in organs in cases with morphine poisioning

作　　者：单亚明[1] 郝春雨[1] 王龙[1] 王大勇[1] 喻少波[1] 陶禄阳[2] 官大威[2] 

机构地区：[1]沈阳市刑事科学技术研究所,辽宁110002 [2]中国医科大学法医学院,辽宁沈阳110001

出　　处：《法医学杂志》2002年第1期9-11,共3页Journal of Forensic Medicine

摘　　要：目的研究吗啡在人体脏器中的分布情况,筛选适于免疫组化方法检测吗啡的脏器。方法用免疫组化SP法对8例吗啡类毒品中毒死亡尸体脑、肾、心、肝等脏器中的吗啡进行定位和半定量观察。结果吗啡主要分布在某些实质细胞的胞浆内,肾脏和脑组织的吗啡含量高,不同器官、不同案例吗啡的分布情况差异较大。结论肾脏和脑是实际检案时用免疫组化方法检测吗啡的理想检材。Objective To investigate the distribution of mophine in organs in cases with morphine poisioning to select ideal organs for immunohistochemical derection. Methods Localization and half quantitation of morphine in the brain, the kidney, the heart,and the liver were studied in 8 cases with morphine poisoning by immunohistochemical SP method. Results Morphine was mainly detected in the cytoplasm of certain parenchymal cells of the organs. The distribution varied greatly with different cases and organs. In the brain and kidney, morphine-positive cells could be easily found. Conclusion The kidney and brain may be the ideal organs for sampling in suspected morphine poisoning cases with.

关 键 词：吗啡类毒品中毒 吗啡 免疫组化 分布 法医鉴定学 

分 类 号：D919.4[医药卫生—法医学]