氯沙坦治疗原发性高血压的疗效和对尿清蛋白的影响  

Efficacy and antiproteinuric effect of losartan in the treatment of essential hypertension

作　　者：程标[1] 蔡力[1] 姜荣建[1] 刘中英[1] 唐英蓉[1] 

机构地区：[1]四川省人民医院心内科,成都610071

出　　处：《医学科技》2002年第1期3-6,共4页

摘　　要：目的:探讨氯沙坦治疗轻、中度原发性高血压的疗效和对尿清蛋白的影响。方法:82例高血压患者随机分两组,氯沙坦组(治疗组,43例)50～100mg·d^(-1)口服,疗程12周;培哚普利组(对照组,39例)4～8mg·d^(-1)口服,疗程12周。治疗前后做动态血压及肝、肾功能、血脂、血糖等检查,测定尿液中清蛋白,血清肌肝及血尿素氮的变化。结果:治疗组降压总有效率75%(33例),降压幅度(以 mmHg 计)收缩压为21,舒张压为13,谷,峰比值收缩压为0.73,舒张压为0.71,对照组总有效率74%(29例),降压幅度收缩压为22,舒张压为12,谷峰比值收缩压为0.71,舒张压为0.72,两组结果相似。治疗后两组尿清蛋白减低(P<0.01)。氯沙坦不良反应轻微。结论:氯沙坦对高血压有确切疗效,干咳发生率低,减少尿清蛋白的排泄,对肾脏有保护作用。Objective:To investigate the efficacy and antiproteinuric effect of losartan in the treatment of mild to moderate essential hypertension.Methods:Fourty-three patients were given gOing to 100mg of losartan once daily.Another 39 patients were given 4rag to 8rag of perindopril once daily,The course was 12 weeks.Ambulatory blood pressure monitoring(ABPM),hepatic and renal function,albuminuria were examined before and after thera- py.Results:The total efficacy rate,amplitude SBP and DBP lowered,and SBP and DBP trough to peak ratio(T/ P)in losartan group were 75%,21mgHg,13mmHg,0.73 and 0.71,respectively,While that in perindopril group was 74%,22mmHg,12mmHg,0.71 and 0.72,respectively(P>0.05).Both drugs appear to lower blood pres- sure adequately while inducing a decrease of urinary protein excretion.Conclusion:Losartan is effective in patients with mild to moderate essential hypertension while reducing urinary protein excretion and incidence of cough.This profile has been hypothesized to be protective against progression of renal function decline.

关 键 词：氯沙坦 培哚普利 高血压 尿清蛋白 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]