2-(1H-咪唑-1-基)-1-(2,3,4-三甲氧基苯)乙酮的合成  

Preparation of 2-(1H-Imidazol-1-yl)-1 (2,3,4-trimethoxyphenyl)ethanone

作　　者：杨松[1] 宋宝安[1] 李正名[2] 廖仁安[3] 

机构地区：[1]贵州大学精细化工研究开发中心,贵阳550025 [2]南开大学国家农药工程中心 [3]南开大学元素有机化学国家重点实验室

出　　处：《应用化学》2002年第5期491-493,共3页Chinese Journal of Applied Chemistry

基　　金：元素有机国家重点实验室开放基金 (2 0 0 2 );国家自然科学基金 (2 9462 0 3 );贵州省优秀人才省长基金 (2 0 0 13 )资助项目

摘　　要：A new compound was synthesized with 1,2,3 trimethoxybenzene as the starting material, followed by acylation of Friedel Crafts, bromination reaction, the nucleophilic N substitution of imidazole . For 2 bromo 1 (2,3,4 trimethoxyphenyl)ethanone in DMF,2 (1H imidazol 1 yl) 1 (2,3,4 trimethoxyphenyl) ethanone was obtained in yield of 62 7%. It was obtained that the best reaction condition which the molar ratio of bromo compound to imidazole will be 1∶5 and the reaction time will be 8 h under low temperature or room temperature. The structure of the product was confirmed by elemental analysis, 1H NMR and IR spectrum analysis.Eight ( Z ) 2 (1 H imidazole 1 yl) 1 (2,3,4 trimethoxy)acetophenoxime esters(Ⅳ) were prepared in 62 1%～84 1% yield by reacting ( Z ) 2 (1 H imidazole 1 yl) 1 (2,3,4 trimethoxy)acetophenoxime(Ⅲ) with acyl chloride in the presence of methylene dichloride and triethylamine. The structures of the new compounds were proved by means of elemental analysis, IR and 1H NMR spectrum data. The relationship between the configuration and the spectral character was discussed.

关 键 词：连苯三醚 咪唑 制备 

分 类 号：O626.23[理学—有机化学]