电针对摇头丸滥用者^(99m)Tc-ECD脑灌注显像及脑功能活动的影响  

EFFECT OF ELECTRONIC ACUPUNCTURE ON REGIONAL BLOOD FLOW AND CEREBRAL FUNCTION IN MDMA ABUSERS

作　　者：时杰[1] 贾少微[2] 李素民[1] 徐国柱[1] 郑继旺[1] 石宇[2] 陈红艳[2] 高宙[2] 李东俊 孙粤立 梁尔军 苗福才 

机构地区：[1]北京大学中国药物依赖性研究所,北京100083 [2]北京大学深圳医院,深圳510084 [3]深圳市公安局强制戒毒所,深圳518019

出　　处：《中国药物依赖性杂志》2002年第2期111-116,共6页Chinese Journal of Drug Dependence

摘　　要：目的·· :用单光子发射计算机断层扫描 (SPECT)脑灌注显像 ,观察电针 (EA)对摇头丸滥用者局部脑血流量(rCBF)及脑功能活动的影响。方法·· :17例摇头丸滥用者和20例健康志愿者 (对照组 )在电针治疗前后进行SPECT检查 ,用脑血流功能变化率 (BCFR % )数学模型进行定量分析 ,评价电针对上述观察指标的影响。结果·· :与对照组相比 ,17例摇头丸滥用者的大脑皮质额叶、颞叶、脑岛、基底节均存在局部脑血流量不同程度的降低,而脑岛、基底节区功能亢进的病理表现 ;电针治疗可显著增加或调整局部脑血流量 ,并改善大脑的功能活动 (P<0.01 ,P<0.001)。结论·· :摇头丸滥用可以导致大脑血液供应减少或病理性增加 ,进而引起中枢神经系统的功能异常 ;针刺治疗对此有显著改善作用 ,提示针刺可以作为一种简便、有效。Objective: To observe the effect of electronic acupuncture(EA) on regional cerebral blood flow (rCBF) and cerebral cell function in 3,4-methylemdioxymethamphetamine (MDMA) abusers with single-photon emission computed tomography (SPECT). Methods: SPECT was performed in 17 MDMA abusers and 20 healthy volunteers (control group) before and after EA treatment. The focus and mirror region were quantified with BFCR% model. Results: rCBF imaging and quantification of bilateral cerebral frontal lobes, temporal lobes,the insula,ipsilateral basal nuclei were decreased significantly in MDMA abuses compared with those of the control group. It was found indirectly that cerebral cell function of MDMA abuse was greater than that of the control group. rCBF imaging and quantification and cerebral cell function improved significantly after EA treatment (P<0.001). Conclusion: There was pathological damage of cerebral blood vessel and cerebral function in MDMA abusers. EA treatment improved cerebral blood supply and stimulated cell function of brain nerve systems, indicating that EA might work as a noninvasive, convenient and effective therapy for the pathological damage of MDMA abuse.

关 键 词：电针 摇头丸 滥用者 脑功能活动 3 4-亚甲二氧基甲苯丙胺 单光子发射计算机断层扫描 局部脑血流量 针刺 

分 类 号：R595.5[医药卫生—内科学]