毒力回归方程b值的毒理学意义及剂量死亡曲线坡度度量的探讨  

On the Toxicological Meaning of b of the Linear Regression Equation and the Measurement of the Slope of Dose/lethal Curve

作　　者：窦丰满[1] 蒋峥[1] 陈云[1] 周忆昭[1] 

机构地区：[1]成都市卫生防疫站

出　　处：《医学动物防制》2002年第3期165-167,共3页Journal of Medical Pest Control

摘　　要：致死量标准差是表示化学品毒性的指标,其大小可以用剂量死亡曲线的坡度度量。本文指出毒力回归方程的b值不能用于表示剂量死亡曲线的坡度,及表示急性毒作用,1/b也不能作为试验精密度指数。应该用S值度量剂量死亡曲线的坡度。S值也是致死量的标准差。S值还可以作为急性毒作用带指标及试验精密度指数。对于概率单位回归LD50计算法,S值计算公式为S=log-1（1/b）。The standard deviation of lethal dose is an important acute toxicity parameter of a chemical substance as LD50 and can be measured by the slope of the dose/lethal curve. This paper indicated that the slope can not be measured by the acute toxicity action zone, and the 1/b can not be the precision indez of the test too. The slope of dose/lethal curve can be measured by the S value. S value is the standard deviation of lethal dose. S value is calculated with the formula S = log-1 (1/b). The relationship between S and MNLD of a chemical substance is discussed.

关 键 词：毒力回归方程 剂量死亡曲线 坡度 LD50计算法 毒理学 曲线坡度 化学品毒性 

分 类 号：R99[医药卫生—毒理学]