哮喘患者血一氧化氮含量与肺通气功能的相关性研究  

RELATIONSHIP BETWEEN NITRIC OXIDE IN BLOOD AND VENTILATIVE FUNCTION OF ASTMATIC PATIENTS

作　　者：刘翱[1] 沈毅[1] 杨伟康[1] 查云[1] 高怡滨[1] 王兴友[1] 李献武[1] 

机构地区：[1]成都军区昆明总医院呼吸内科,昆明650032

出　　处：《西南国防医药》2002年第2期105-106,共2页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的 :研究哮喘患者血一氧化氮 (NO)含量增高与其气道口径及气道反应性之间的相互关系。方法 :对 2 1例哮喘患者分别测定急性发作期和缓解期血NO含量及 1秒钟用力呼气容积 (FEV1)、1秒钟用力呼气容积占预计值比例(FEV1% ) ,最大呼气流量 (PEF)、最大通气量 /1秒用力肺活量比 (MVV/FEV1)。结果 :⑴哮喘急性发作期血NO含量显著高于缓解期 ;⑵急性发作期哮喘病人血NO增高与FEV1、FEV1%、PEF呈显著相关性 ,与MVV/FEV1无明显相关性。结论 :哮喘患者急性发作期血NO含量增高与其气道阻塞有关 。Objective: To study the relationship between the level of nitric oxide(NO) in blood and the ventilative function of asthmatic patients. Method: It was measured the level of NO in blood and forced expiratory volume in one second(FEV 1), ratio of FEV 1 to expected volume(FEV 1%), peak expiratory flow(PEF) and ratio of maximal voluntary ventilation to FEV 1(MVV/FEV 1) of 21 asthmatic patients during acute attack and remission. Result: The level of NO in blood of these patients during acute attack was significantly higher than that during remission. The increased NO was significant correlation with FEV 1,FEV 1% and PEF, and was not correlation with MVV/EFV 1. Conclusion: The increased NO during acute attack is relative to obstruction of respiratory tract, but not to high reaction of respiratory tract.

关 键 词：相关性研究 哮喘 NO 肺功能试验 

分 类 号：R562.250.2[医药卫生—呼吸系统]