血塞通注射液药代动力学研究  

Study on Pharmacokinetics of Xuesaitong Injection

作　　者：王艳萍[1] 孟庆彪[1] 王伟东[1] 史沛海[1] 

机构地区：[1]解放军第208医院,长春市130062

出　　处：《中国药房》2002年第3期144-145,共2页China Pharmacy

摘　　要：目的 :测定血塞通注射液在兔体内药代动力学参数。方法 :采用高效液相色谱法 ,以血塞通注射液中人参皂苷Rg1 为指标进行测定。色谱柱 :HypersilC18(4 6mm×250mm ,5μm) ;流动相 :乙腈 -水 (3∶7) ;检测波长 :210nm ;流速 :1ml/min。结果 :血塞通注射液静脉注射后在兔体内呈二室模型分布 ,经PKBP -NI程序处理 ,得到其药代动力学参数。结论 :该法简便、准确、可靠 ,可用于测定血浆中人参皂苷Rg1。OBJECTIVE:To determine the pharmacokinetic parameters of Xuesaitong injection in rabbits.METHODS:Using ginsenoside Rg1 in Xuesaitong injection as a marker,the determination was carried out with HPLC.The detection conditions were:mobile phase,acetonitrile-water(3∶7);chromatgraph column,Hypersil C18(250mm×4.6mm,5μm);detection wavelength,210nm and flow rate,1 ml/min.RESULTS:After intravenous injection,the plasma concentration time data was found to be in accordance with the 2-compartment model in rabbits.The pharmacokinetic parameters were obtained with PKBP-NI.CONCLUSION:The method is simple,accurate and reliable.It could be used to determine the concentration of ginsenoside Rg1 in plasma.

关 键 词：血塞通注射兴 药代动力学 人参皂苷RG1 高效液相色谱法 中药 

分 类 号：R285[医药卫生—中药学]