芳香开窍药和祛痰药对中枢神经系统兴奋性的影响  

Effects of FXKQY and QTY on CNS Excitability

作　　者：方永奇[1] 邹衍衍[1] 李羚[1] 魏刚[1] 林双峰[1] 

机构地区：[1]广州中医药大学第一附属医院,510405

出　　处：《中医药研究》2002年第3期40-42,共3页Research of Traditional Chinese Medicine

基　　金：广东省中医药管理局资助项目(No.97189)

摘　　要：目的:观察芳香开窍药和祛痰药对CNS兴奋性的影响。方法:灌胃给药 5次,观察睡眠实验、中枢兴奋实验和耐缺氧实验。结果:①芳香开窍药能缩短戊巴比妥钠持续睡眠时间,以冰片的作用最强;冰片还能延长苯巴比妥钠入睡时间,而石葛蒲则能延长苯巴比妥钠睡眠持续时间。祛痰药对睡眠实验影响不大。②芳香开窍药能对抗苦咪毒兴奋CNS,起镇静抗惊厥作用(府香的作用未达到统计学意义);而祛疾药中只有瓜萎有此作用,其它药对此无明显作用。③芳香开窍药石葛蒲、冰片能延长小鼠耐氧存活时间;而祛疾药无此作用,结论:芳香开窍药对CNS兴奋性有较强的双向调节作用;而祛疾药对 CNS兴奋性的作用绥弱;Objective: To observe the effects of FXKQY and QTY on CNS excitability. Methods : Sleep experiment, CNS excitability and a-bility to bear anoxic were observed by giving FXKQY and QTY 5 times. Results: FXKQY could shorten the sleep time caused by pentobarbital sodium, of which Borncol had best effect, but QTY had no evidence effect on that. FXKQY could antagonize pierotoxin to exciting CNS and resist convolusion and QTY had no effect but Trichosanthis. FXKQY T could prolong alive time of anoxic mice but QTY could not . Conclusion: FXKQY has double - side effect on CNS excitability, but QTY has a little effects.

关 键 词：芳香开窍药 祛痰药 中枢神经系统兴奋性 实验研究 

分 类 号：R285.5[医药卫生—中药学]