基于VB的主成分回归计算分光光度法同时测定感冒液成分的研究  

Research into Simultaneous Spectrophotometric Determination of Components in Cough Syrup by Principal Component Regression Method

作　　者：张立庆[1] 吴晓华[2] 唐曦[1] 朱仙良[1] 苏文庭[2] 

机构地区：[1]浙江科技学院生物与化学工程学系,浙江杭州310012 [2]浙江大学材料与化工学院,浙江杭州310027

出　　处：《光谱学与光谱分析》2002年第3期427-429,共3页Spectroscopy and Spectral Analysis

基　　金：浙江省分析测试基金项目 (项目编号 0 1 0 1 8)

摘　　要：主成分回归 (PCR)分光光度法是近年来发展起来的计算分光光度法之一。本文将主成分回归分光光度法应用于感冒液中对乙酰氨基酚、扑尔敏、咖啡因、对氨基酚和愈创木酚甘油醚五组分含量的分析研究 ,详细介绍了基本原理和具体的分析步骤。运用计算机VB语言对实验数据进行回归分析 ,实验结果表明主成分回归分光光度法对样品各组分的平均回收率在 96 4 3%～ 10 7 14 % ,样品不经分离即可同时测定 。Principal component regression (PCR) method is used to analyse five components: acetaminophen, p-aminophenol, caffeine, chlorphenamine maleate and guaifenesin. The basic principle and the analytical step of the approach are described in detail. The computer program of LHG is based on VB language. The experimental result shows that the PCR method has no systematical error as compared to classical method. The experimental result shows that the average recovery of each component is all in the range from 96.43 % to 107.14 %. Each component obtains satisfactory result without any pre-separation. The approach is simple, rapid and suitable for the computer-aid analysis.

关 键 词：主成分回归 计算分光光度法 速效感冒液 同时测定 成分分析 咖啡因 对氨基酚 愈创木酚甘油醚 乙酰氨基酚 扑尔敏 

分 类 号：R927.2[医药卫生—药学]