电针对吗啡戒断大鼠β-EP免疫调节作用的影响  

Effect of Electroacupuncture on Immunoregulation of β-EP in Rats with Morphine Abstinence Syndrome

作　　者：宋小鸽[1] 唐照亮[1] 章复清[1] 陈全珠[1] 侯正明[1] 朱庆丰[1] 

机构地区：[1]安徽中医学院针灸经络研究所,合肥230038

出　　处：《针刺研究》2001年第4期303-306,共4页Acupuncture Research

基　　金：安徽省教委自然科学基金项目;安徽省重点科研项目;合肥市科委重点科研项目

摘　　要：本文观察电针“足三里”穴对吗啡戒断大鼠β EP免疫调节作用的影响 ,探讨针刺祛毒扶正的作用机理。结果表明 ,电针组血清和垂体内 β EP含量增加 ,IL 1、IL 2升高 ,免疫器官重量和体重比吗啡对照组明显增加 ,垂体β EP与IL 1之间呈正相关趋势。提示针刺脱毒扶正 ,改善戒断症状的作用可能与βObjective: To observe the effect of electroacupuncture (EA) of'Zusanli'(ST 36) on the immunoregulating action of β EP in rats with morphine abstinence syndrome for studying the mechanism of acupuncture in dispelling toxin and reinforcing body resistance. Methods: A total of 24 rats were divided into control group (n=8), morphine group (n=8) and EA group (n=8). Rat morphine abstinence syndrome model was made by intramuscular injection of morphine (20 mg/kg for the first day, double, 3 times and 4 times for the following 3 days, and 100 mg/kg for the 5th ～8th day). EA (2 Hz ～100 Hz, 10 V, continuous waves) was applied to 'Zusanli' (ST 36), once daily and continuously for 8 days. Serum IL 1, IL 2, β EP contents and β EP level of hypophysis were detected using radioimmunoassay.Results: The results showed that in comparison with morphine group, the rat body weight, spleen weight and thymus gland weight, β EP in serum and hypophysis, Serum IL 1 and IL 2 of EA group and normal group increased significantly (P<0.05 ～0.001). There was a positive correlation between β EP of hypophysis and IL 1 in EA group. Conclusion: Results suggest that the effect of acupuncture in improving symptoms of abstinence symposium might be related to favorable regulation of β EP on cellular factors.

关 键 词：电针 吗啡戒断 免疫调节 Β-EP 

分 类 号：R245.97[医药卫生—针灸推拿学] R259.955[医药卫生—中医临床基础]