扶正抗癌方对大鼠移植性肝癌P_(53)、nm_(23-H1)表达的影响  

Influence of Fuzheng Anti-carcinoma Prescription (FAP) on P_(53) and nm_(23-H1) Expressions in Rats with Implanted Hepatoma

作　　者：韩克起[1] 周立棠 黄传继[1] 

机构地区：[1]中国人民解放军第150医院,河南洛阳471031

出　　处：《中西医结合肝病杂志》2001年第4期222-223,共2页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：探讨扶正抗癌方(简称FAP)对大鼠移植性肝癌P_(53)、nm_(23-H1)基因表达的影响,研究其抗肿瘤作用机制。方法:40只大鼠移植性肝癌模型随机分为生理盐水组(NS)及FAP组,每组20只,分别灌胃10d,测瘤组织P_(53)、nm_(23-H1)水平。结果:NS级P_(53)阳性表达率为40％,nm_(23-H1)阴性表达率15％;FAP组P_(53)阳性表达率为70％,nm_(23-H1)阴性表达率70％,二者相比,P>0.05及P<0.01。结论:FAP有调节荷瘤鼠P_(53)及nm_(23-H1)基因表达作用,其抗癌作用可能作用于以上某一个或多个环节。To explore the influence of FAP on P53 gene and nm23-H1 gene expression in rats with implanted hepatoma. Methods: Forty rats with implanted hepatoma were divided into group FAP and group NS. Each group had 20 cases. After 10 days treatment, the P53 gene and nm23-H1 gene expression in the tissues of implanted hepatoma were detected. Results: The percents of P53 gene positive expression in the two groups were 40% and 70% (P>0. 05), and the percents of nm23-H1 gene negative expression were 15% and 70% (P<0. 01). Conclusions: FAP could increase P53 gene positive expression and nm23-H1 gene negative expression. The effects of anti-carcinoma of FAP may be acted on the one or several accesses above.

关 键 词：抚正抗癌方 移植性肝癌 P53 NM23-H1 表达 

分 类 号：R273[医药卫生—中西医结合]