用^(45)Ca研究中药的钙拮抗作用及机理  

Study on Ca^(2+) Antagonistic Effect and Mechanism of Chinese Herbal Drugs Using ^(45)Ca

作　　者：杨远友[1] 刘宁[1] 莫尚武[1] 邱明丰[1] 金建南[1] 廖家莉[1] 

机构地区：[1]四川大学原子核科学技术研究所辐射物理及技术教育部重点实验室,四川成都610064

出　　处：《同位素》2002年第2期69-73,共5页Journal of Isotopes

基　　金：国家自然科学基金(19775034);核工业基金(Y7197QY414)

摘　　要：用^(45)Ca跨膜测量技术研究了中药及治疗冠心病中药复方对大鼠主动脉平滑肌细胞膜Ca^(2+)通道的影响。结果表明:西红花、川红花、地奥心血康等对平滑肌细胞膜电压依赖Ca^(2+)通道(PDC)和受体操纵Ca^(2+)通道(ROC)有阻滞作用,其中以西红花作用最强;中药复方中全方与各功能药均不影响静流(Leak),对ROC、PDC均有明显阻滞作用。藿香与佩兰均是以正己烷提取组分的钙拮抗作用最强;藿香的活性成分有5个,佩兰的活性成分有2个。The Ca2+ antagonistic effect and mechanism of Chinese herbal drugs are studied by 45Ca. The results indicate that potential-dependent Ca2+ channel (PDC) and receptor-operated Ca2+ channel (ROC) in cell membranes of smooth muscle can be blocked by vseveral Chinese herbal drugs, including as Crocus sativus L. , Carthamus L. , Di-ao-xin-xue-kang(DAXXG) and Ginkgo biloba L. leaves. Among them Crocus sativus L. has the strongest antagonistic effect on Ca2+ channel, while Ginkgo biloba L. leaves has no obvious effect. The whole prescription and the other functional drugs have significant effect on ROC and PDC. The compositions extracted by hexane have the strongest antagonistic. The wrinkled giant hyssop have five active compositions and Pei-lan have two active compositions.

关 键 词：中药 钙拮抗作用 钙抗结机理 钙45 钙抗结剂 跨膜测量 冠心病 中药复方 治疗 

分 类 号：R817.52[医药卫生—影像医学与核医学] R286.2[医药卫生—放射医学]