3—[4—2(羟基乙基)哌嗪基]甲基—联苯对二酚对体外培养心肌细胞作用的研究  

Effects of 3-[4-2(hydroxyethyl) piperazinyl] methyl-P-dihydoxydiphenyl on Cultured Heart Cells in vitro

作　　者：臧玉英[1] 王道生[1] 曹观坤 

机构地区：[1]苏州医学院药理教研室,江苏省苏州市215007 [2]中国药科大学制药化学教研室,江苏省南京市210009

出　　处：《现代应用药学》1991年第1期1-4,共4页

摘　　要：3—[4—2(羟基乙基)哌嗪基]甲基—联苯对二酚(N_(22))为苯酚的衍生物,属非甾体类抗炎药。本文研究了N_(22)对体外培养心肌细胞的作用,结果表明N_(22)对大鼠体外培养心肌细胞搏动有明显的负性频率作用,并伴有搏动强度减弱作用;对自发性或由乌豆碱诱发的速发型心律失常有明显的对抗作用。3-[4-2(hydroxyethyl) piperazinyl] methyi-P-dlhydoxydiphenyl derived from phenol was a nonsteroidal antimflammatory drug possessing antimflammatory and antipyretic-analgesic activities. Effect of 3-[4-2(hydroxyethyl)piperazingl] methyl-P-dihydoxydiphenyl on cultured neonatal rat heart cells were investigated. It was shown that 3-[4-2(hydroxyethyl)piperezinyl] methyl-Pdihydoxydlphenyl had the significant negative chronotropic and negative inotropic actions, It significantly inhibited spontaneous and aconitine-induced tachyrrythmias in cultured myocardial cells.

关 键 词：抗炎药 心律失常 心肌细胞 培养 

分 类 号：R972.2[医药卫生—药品]