利福定固体分散物的制备及生物利用度测定  

The Preparation and Determination of Bioavailability of Rifandin Solid Dispersion

作　　者：何仲贵[1] 唐星[1] 蔡玉珉[1] 

机构地区：[1]沈阳药学院药剂教研室,沈阳市110015

出　　处：《现代应用药学》1991年第2期17-18,共2页

摘　　要：用溶媒法制备了利福定固体分散物。经X—射线衍射实验证明,利福定在固体分散物中呈无定形或以分子状态分散于载体中。固体分散物2小时的体外溶出量和人体生物利用度分别较原药提高了88％和21.8％。Rifandin Solid Dispersion (RSD) were prepared by using 'solvent method'. Result showed that Rifandin (R) was dispersed in carrier with amorphous or molecularity through x-ray diffract experiment. The disolution amount of R in RSD was 88％ more than that of untreated R in imitated gastric jules. The bioavailability of RSD was 21.8％ more than that of untreated R in human body.

关 键 词：利福定 固体分散物 生物利用度 

分 类 号：R944.2[医药卫生—药剂学]