TRH对吗啡镇痛作用的影响及其对呼吸、循环和中枢神经系统的作用  

The Effect of TRH on Analgesia of Morphine and Circulation, Resparation and Central Nervous Systems in Animals

作　　者：刘良明[1] 胡德耀[1] 陈惠孙[1] 廖世海 李丽 范成国[1] 

机构地区：[1]第三军医大学野战外科研究所,重庆市630042

出　　处：《现代应用药学》1991年第4期1-4,13,共5页

摘　　要：本文就TRH与NAL拮抗吗啡类药物的镇痛、成瘾及制动作用作了比较研究,并观察了TRH对呼吸、循环及中枢神经系统的作用。结果发现TRH不能拮抗吗啡类的镇痛、成瘾及制动作用。TRH(10μg icv或5mg/kg iv)可显著升高正常动物平均动脉压,加快心率及呼吸。TRH腹腔注射可缩短戊巴比妥钠的睡眠时间,并呈一定剂量依赖关系。This paper has made a comparison about the antagonism to analgesia, addict and 'trig' of Morphine between TRH and NAL. In our experiments, TRH's effects on resparation, circulation and central nervous systems were also observed. The results shows that TRH does nol have the abjljty of antagonism to analgesia, addict and 'Trig' of morphine. TRH (10 μg icv or 5 mg/kg iv) may obviously raice normal animal's BP, and qkicken the resparatton measures and heart rate. TRH may also shorten the sleep duration of Pentobarbital Sodium in mice, and this effect appears Certain dose-dependence.

关 键 词：TRH 纳洛酮 吗啡 镇痛作用 

分 类 号：R971.1[医药卫生—药品]