交联补强硅橡胶包埋18-甲基炔诺酮的释放行为  

Drug Release System Based on Silicone Rubber and Levo-norgestrel

作　　者：张春雪[1] 盛京[1] 马季涛[1] 

机构地区：[1]天津大学材料科学与工程学院

出　　处：《应用化学》2002年第6期597-599,共3页Chinese Journal of Applied Chemistry

摘　　要：The medical grade poly(vinylmethyl siloxane)(PVMS) and silica filled PVMS were crosslinked with benzoyl peroxide(BPO). The glass transition of the crosslinked silicone rubber was evaluated by measurment of thermally stimulated current(TSC). The releasing rate of 1 norgestrel(LNG) through the membrane of the vulcanized silicone rubber in saturated physiological salt solution and that from the intrauterine device(IUD) were determined. The results showed that the drug deli very behavour was influenced by the structure of PVMS molecules which were controlled by the content of BPO and silica used in vulcanization of PVMS. The burst effect at first stage of drug delivery was observed probably due to the interaction between LNG and macromolecules. The releasing curve of LNG from IUD could be kept constant for period of half a year.The medical grade poly(vinylmethyl siloxane)(PVMS) and silica filled PVMS were crosslinked with benzoyl peroxide(BPO). The glass transition of the crosslinked silicone rubber was evaluated by measurment of thermally stimulated current(TSC). The releasing rate of 1 norgestrel(LNG) through the membrane of the vulcanized silicone rubber in saturated physiological salt solution and that from the intrauterine device(IUD) were determined. The results showed that the drug deli very behavour was influenced by the structure of PVMS molecules which were controlled by the content of BPO and silica used in vulcanization of PVMS. The burst effect at first stage of drug delivery was observed probably due to the interaction between LNG and macromolecules. The releasing curve of LNG from IUD could be kept constant for period of half a year.

关 键 词：释放行为 甲基乙烯基硅橡胶 交联 左旋-18-甲基炔诺酮 包埋 药物释放系统 

分 类 号：R944.9[医药卫生—药剂学]