二茂铁基苯甲酸四乙酰葡萄糖酯的合成及其抗贫血活性  

Synthesis and Antianemic Activity of Tetraacetyl glucosyl esters of Ferrocenyl Benzoic Acid

作　　者：陈勇[1] 刘惠英[2] 付莎莉[2] 

机构地区：[1]江苏石油化工学院化工系,常州213016 [2]武汉大学化学系

出　　处：《应用化学》2002年第6期603-605,共3页Chinese Journal of Applied Chemistry

摘　　要：Three tetraacetyl glucosyl esters of the ferrocenyl benzoic acids(compounds Ⅱ o,Ⅱ m,Ⅱ p) have been synthesized using a phase transfer catalyst(CTAB) in dichloroethane/water at 50 ℃. Their structures have been confirmed by elemental analysis, IR, 1H NMR and MS. The compounds were found to have antianemic activity. The RBC and HB values of the tested anemic rats were increased by 72 0% and 126 4%, respectively after abdomen injection.Three tetraacetyl glucosyl esters of the ferrocenyl benzoic acids(compounds Ⅱ o,Ⅱ m,Ⅱ p) have been synthesized using a phase transfer catalyst(CTAB) in dichloroethane/water at 50 ℃. Their structures have been confirmed by elemental analysis, IR, 1H NMR and MS. The compounds were found to have antianemic activity. The RBC and HB values of the tested anemic rats were increased by 72 0% and 126 4%, respectively after abdomen injection.

关 键 词：二茂铁基苯甲酸乙酰葡萄糖酯 合成 抗贫血活性 抗贫血剂 结构 

分 类 号：TQ463[化学工程—制药化工] R973.3[医药卫生—药品]