苯巴比妥的二次微分简易示波伏安法测定  

Simple Oscillographic Voltammetry for Direct and Indirect Determination of Phenobarbital

作　　者：于浩[1] 张宏芳[1] 郑建斌[1] 

机构地区：[1]西北大学电分析化学研究所,陕西西安710069

出　　处：《分析测试学报》2002年第3期10-12,共3页Journal of Instrumental Analysis

基　　金：国家自然科学基金资助项目 (29775018);国家教育部高等学校骨干教师资助计划项目(GG -150-71006-2877);陕西省教育厅自然科学专项基金资助项目(01JK076)

摘　　要：利用苯巴比妥的示波特性 ,分别建立了在0.2mol/LKOH和1.0×10-4mol/LCd2 +-0.1mol/L硼砂底液中直接和间接测定苯巴比妥的二次微分简易示波伏安法 ;直接测定和间接测定的线性范围分别为1.0×10 -5mol/L～1.0×10 -4mol/L和4.0×10 -6mol/L～8.0×10 -5mol/L ;检出限分别为8×10 -6mol/L和2×10 -6mol/L;在直接测定中 ,对6.000×10 -5mol/L苯巴比妥进行10次测定的RSD为4.5 % ;间接测定中 ,对2.000×10 -5mol/L苯巴比妥进行10次测定的RSD为2.6 % ;这一研究表明对于一些在示波分析中灵敏度不高或本身没有示波活性的药物 ,可以利用其与金属离子生成沉淀的方法间接测定 ,从而提高药物测定的灵敏度。Based on the oscillographic characteristics of phenobarbital, a direct and an indirect method for the determination of phenobarbital in tablets are presented by second _ order differential simple oscillographic voltammetry in base solution of 0.2 mol/L KOH and 1.0×10-4 mol/L Cd2+-0.1 mol/L Na2B2O7, respectively. The linear range and detection limit for the direct method are 1.0×10-5～1.0×10-4 mol/L and 8×10-6 mol/L, respectively, whereas the linear range and detection limit for the indirect method are 4.0×10-6～8.0×10-5 mol/L and 2×10-6 mol/L, respectively. The RSD(n=10) for the direct determination of 6.000×10-5 mol/L and indirect determination of 2.000×10-5 mol/L of phenobarbital are 4.5% and 2.6%, respectively. The investigated results show when a direct method for the determination of a medicine ingredient is not sensitive or the ingredient has no oscillographic activity, an indirect oscillographic method can be successfully used based on precipitation of the ingredient with metal ions, and thus broaden oscillographic analysis application.

关 键 词：二次微分简易示波伏安法 测定 示波分析 苯巴比妥 药物含量测定 

分 类 号：R971.2[医药卫生—药品] R927.2[医药卫生—药学]