美洛昔康对大鼠致畸敏感期的毒性试验研究  

Teratologic Study on Meloxicam in Rats

作　　者：陆益红[1] 金卫红[1] 汪岱迪[1] 

机构地区：[1]江苏省药品检验所,南京210008

出　　处：《江苏药学与临床研究》2001年第2期5-7,共3页Jiangsu Pharmacertical and Clinical Research

摘　　要：美洛昔康在受孕大鼠致畸敏感期(受孕后第6～15天)给药,剂量分别为7.0,3.5,1.8 mg/kg。结果未发现美洛昔康对胎鼠有致畸作用,但该药可使胎鼠体重减轻,吸收胎和死胎增多,骨骼发育迟缓,尤以给予高剂量美洛昔康时明显。Meloxicam (MX) was studied for its adverse effects on pregnant rats and their fetuses. Rats were dosed orally at 7. 0,3. 5,1.8 mg/kg respectively, during the teratologically sensitive period, i. e. from the 6lh day through 15lh of gestation. The results showed that MX might induce embryotoxicity, as compared to the control, i. e. 0. 5% CMC. It increased resorptive fetuses and dead fetuses, reduced the body weight of the fetuses and retarded skeletogeny, especially at high dosage. But no malformation of survial fetuses was observed at every dosage. Therefore, MX is not teratogenic for rats.

关 键 词：美洛昔康 致畸 胚胎毒性 

分 类 号：R978.7[医药卫生—药品] R965.3[医药卫生—药学]