银杏外种皮多糖对免疫功能低下小鼠IL-2活性及sIL-2R的影响  

Influence of Ginkgo biloba exocarp polysaccharides (GBEP) on interleukin-2(IL-2) activity and solubility interleukin-2 receptor (sIL-2R) level in mice under lower immune function

作　　者：陈华圣[1] 许爱华[1] 王翊[1] 王茜 王晓玲 

机构地区：[1]扬州大学医学院 [2]扬州大学临床医学院,扬州225001

出　　处：《中药药理与临床》2001年第4期17-19,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：江苏省教育厅自然科学基金资助项目 (项目编号 :99KJD360 0 0 1 );江苏省科技厅社会发展基金资助项目 (项目编号 :BS2 0 0 0 0 86)

摘　　要：目的 :观测银杏外种皮多糖对免疫功能低下小鼠IL 2活性及sIL 2R的影响。方法 :用银杏外种皮多糖给荷瘤小鼠及环磷酰胺损伤小鼠灌胃治疗 ,分别检测小鼠脾淋巴细胞IL 2活性及血清sIL 2R含量。结果 :银杏外种皮多糖可促进荷瘤小鼠及CTX损伤小鼠脾淋巴细胞的IL 2活性 ,并减少其血清sIL 2R的形成。结论 :银杏外种皮多糖可促进荷瘤小鼠及CTX损伤小鼠的免疫功能。Objective: To study the influence of Ginkgo biliba exocarp polysaccharides (GBEP) on interleukin 2 (IL 2) activity and solubility interleukin 2 receptor (sIL 2R) level in mice under lower immune function. Methods: GBEP was orally administrated to sarcoma 180 (S 180 ) bearing mice and cyclophosphamide (CTX) intoxicated mice. The IL 2 activity in the spleen lymphocyte cells of S 180 bearing mice, CTX intoxicated mice and the contents of sIL 2R in the both kinds of mice's blood were checked. Results: GBEP could promote IL 2 activity the decreased sIL 2R contents in S 180 bearing mice. Similar effects were observed in CTX intoxicated mice. Conclusion: GBEP may promote immune function in S 180 bearing mice and CTX intoxicated mice.

关 键 词：银杏外种皮多糖 免疫功能低下 IL-2 SIL-2R 

分 类 号：R285.5[医药卫生—中药学]