清热灵颗粒药效学研究  

The Pharmacodynamic Study of Qingreling Granule

作　　者：郑高利[1] 张信岳[1] 陈凯[1] 孟倩超[1] 尹秀[1] 田燕华 丁晓雅 

机构地区：[1]浙江省医学科学院药物研究所,杭州310013 [2]正大青春宝药业有限公司,杭州310023

出　　处：《中药药理与临床》2001年第4期30-32,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：清热灵颗粒能明显减轻内毒素所致家兔发热 ;抑制角叉菜胶致大鼠足肿胀 ;降低二甲苯致小鼠耳廓肿胀 ,抑制醋酸引起的小鼠腹腔毛细血管通透性异常升高 ;对金黄色葡萄球菌腹腔染菌致小鼠死亡具有明显的保护作用 ,体外抑菌试验显示对金黄色葡萄球菌、肺炎球菌、肺炎杆菌及大肠杆菌等均具有明显的抑制作用。表明清热灵颗粒具有明显的解热、抗炎和抗菌作用。Qingreling Granule (QRL) significantly inhibited pyrexia induced by endotoxin in rabbit, depressed swelling of paw and ear in mice induced by carrageenine and dimethylbenzene respectively; inhibited the abnormal increase of celiac capillary heperpermeability induced by acetic acid in mice. In vivo it decreased the mortality of mice induced by celiac infection of Stephylococcus aureus, in vivo inhibited the growth of Stephylococcus aureus, Pneumococcus, Pneumobacillus and Escherichia coli, the MICs were between 25 and 50mg/ml while the MBCs 51 and 204 mg/kg. This results indicated that QRL possessed antifebrile, anti inflammation and antibacterial effects.

关 键 词：药效学 清热灵颗粒 解热 抗炎 抗菌 

分 类 号：R285.5[医药卫生—中药学]