北豆根片的毒理学研究  

The Studies on Toxicity of Beidougen (Merispermum dauricum) Tablets

作　　者：胡丽萍[1] 张惠颖[1] 赵秀萍[1] 马杰[1] 

机构地区：[1]辽宁省中医研究院,沈阳110034

出　　处：《中药药理与临床》2001年第3期32-34,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的 :观察口服北豆根片的急性毒性和长期毒性。方法 :小鼠ig北豆根片 1次后观察 7天 ,计算LD50 及其 95 %可信限 ;大鼠分别ig北豆根片 1 2 0 g/kg ,0 3 6g/kg和 0 11g/kg ,每天 1次连续 6周 ,停药后继续观察 2周 ,测试大鼠体重、血液学、血液生化学、脏器系数及组织病理学变化。结果 :北豆根片小鼠一次ig的LD50 及其 95 %可信限为 5 96 (5 2 4～ 6 79) g/kg。北豆根片大鼠ig的长期毒性试验结果为 :停药 2 4h ,1 2 0g/kg剂量组大鼠的体重、肝、脾、肾上腺的脏器系数和肝、脾的病理组织学检查明显异常 ;0 3 6 g/kg剂量组大鼠的体重和肾上腺的脏器系数明显异常。停药 2周后 ,上述异常改变恢复正常。 0 11g/kg剂量组大鼠的各项检查均未见明显异常。结论 :北豆根片ig小鼠。Objective:[WT5”BZ] to observe the acute and subacute toxicity of Beidougen tablets (BT), a total alkaloids of Merispermum dauricum, by oral administration to provide the reference data for the using in clinics. [WT5”HZ]Methods:[WT5”BZ] BT was administered orally to mice which would be observed for 7 days and LD 50 and its 95% confidence limit of BT would be calculated; BT was also administered orally to 3 groups rats once a day for 6 weeks and the examinations of body weight, hematology, hematobiochemical, coefficient of organs (heart, liver, spleen, lungs, kidneys, adrenals, testes, prostate, pancreas, uterus) and histomorphology of organs would be carried out 6 weeks after ig and 2 weeks after stopping ig. [WT5”HZ]Results:[WT5”BZ] the value of LD 50 and its 95% confidence limit by ig to mice of BT was 5.95 (5.24～6.79)g/kg. The results of subacute toxicity by ig to rats were as follows: at 1.20g/kg and 0.36g/kg doses, BT effected the body weight, the coefficient of liver, spleen and adrenals, the histomorphology of liver and spleen 24 hours after stopping ig and above effects dissapeared 2 weeks after stopping ig. [WT5”HZ]Conclusion:[WT5”BZ] BT had some toxicity to mice and rats by oral administration. [WT5”HZ]

关 键 词：北豆根片 毒理学 急性毒性 长期毒性 

分 类 号：R285.5[医药卫生—中药学]