广枣总黄酮抗氧化作用的实验研究  

Experimental study on anti-oxidation effects of Total Flavonoids of Fructus Chorspomias (TFFC)

作　　者：包保全[1] 张昕原[1] 乌日娜[1] 孙福祥[1] 巴根那[1] 李宝山[1] 

机构地区：[1]内蒙古民族大学实验中心,通辽028041

出　　处：《中药药理与临床》2001年第2期8-10,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：内蒙古自然科学基金资助项目!971 30 31

摘　　要：目的 :研究广枣总黄酮 (TFFC)抗自由基、抗氧化的作用。方法 :在O2 ·、·OH及MDA生成体系中分别观察TFFC对O2 ·、·OH及OxyHb和MetHb含量的影响 ;用ADR大白鼠模型及培养的乳鼠心肌细胞 ,观察TFFC对LDH、AST、CK以及培养心肌细胞中LDH及MDA影响。结果 :TFFC能使ADR模型升高的心肌LDH、AST、CK含量降低 ,而心、肝、红细胞中抗氧化酶SOD、GSH Px、CAT上升 ,脂质过氧化物 (MDA)下降 ,并降低ADR损伤的培养心肌细胞中LDH及MDA含量。结论 :TFFC通过抗自由基、抗氧化对氧合血红蛋白及心。AIM: To study the protective effect of TFFC on peroxidation in rat's cardiac muscle and cultured cardiomyocytes. [WT5”HZ]Methods:[WT5”BZ] In O 2 · ,·OH and MDA productive system, the effect of TFFC on the content of O 2 · ,·OH,Oxy Hb and Met Hb was determined; after TFFC was administered on rats with Adriamycin induced perosidation, activities of LDH、AST、CK in rat's serum and the content of MDA in cardiac muscle, the activity of LDH and content of MDA in cultured suckling rat cardiomyocytes were determined. [WT5”HZ]Results:[WT5”BZ] The content of LDH、AST、CK in the rat's cardiac muscle decreased in TFFC group, when activities of SOD、GSH Px、CAT increased gradually, activities of MDA decreased. The activity of LDH and MDA in culture fluid and in cultured cardiomyocytes decreased too. [WT5”HZ]Conclusion:[WT5”BZ] TFFC can protect heart, liver and haemoglobin by scavenging free radicals and inhibiting lipid peroxidation.

关 键 词：广枣总黄酮 阿霉素 自由基 抗氧化 心酶谱 心肌细胞 

分 类 号：R285.5[医药卫生—中药学]