长期接触低浓度二硫化碳对工人血脂影响的研究  

Study of Long-term Exposure to Lower Concentration of Carbon Disulfide on Cardiovascular System of Workers

作　　者：彭晓霞[1] 谭晓东[1] 陈冠民[1] 毕勇毅[1] 王福元[1] Michel Vanhoorne 

机构地区：[1]武汉大学医学院卫生学教研室,430071

出　　处：《中国公共卫生》2002年第6期683-684,共2页Chinese Journal of Public Health

基　　金：比利时ABOS基金资助

摘　　要：目的　研究工人长时间低浓度CS2 接触对心血管系统的影响。方法　对 367名二硫化碳 (CS2 )接触工人及1 2 5名非接触者进行心血管功能检查。结果　在高剂量暴露组工人中 ,血清总胆固醇 (TC) ,载脂蛋白B(ApoB)均较高于对照组 ,且差异有显著性意义 (P <0 0 5)。经多元逐步回归发现 ,CS2 暴露对血清总胆固醇和载脂蛋白B起正贡献作用 ,偏回归系数分别为 0 1 1 3 2 ,0 0 393。结论　长时间低浓度暴露于CS2Objective To evaluate viscose rayon workers for cardiovascular manifestations resulting from exposure to carbon disulfide at the level of the threshold limit value of 10mg/m 3 long term.Methods In a cross sectional study we investigated 367 workers occupationally exposed to CS 2 and a control group( n =125).Results there was a singificant increase in the serum levels of total cholesterol and ApoB( P <0 05).These differences could also be confirmed statisically after multiple stepwise regression analysis.No differences were noted as to concentration of Hdl ch?Ldl ch?ApoA I and so on among three groups.Conclusion The findings may indicate that exposure to CS 2 can increase the levels of total cholesterol and ApoB in the serum,namely,low level exposure to CS 2 long term could increase the risk of workes developing CS\-2 indued cardiovascular abnormalities.

关 键 词：二硫化碳 心血管系统 血清脂蛋白 职业性危害 

分 类 号：R135.14[医药卫生—劳动卫生]