长期饮用纯净水对大鼠心肾相关指标的影响  

Effects on Heart and Kidney-Related Clinical Parameters of Rats Drinking Purified Water for Long Time

作　　者：舒为群[1] 李国平[1] 赵清[1] 郭乔楠[2] 郭劲松[3] 龙腾锐[3] 

机构地区：[1]第三军医大学环境卫生学教研室,重庆400038 [2]第三军医大学病理学研究所 [3]重庆大学城市建设学院

出　　处：《中国公共卫生》2002年第6期706-708,共3页Chinese Journal of Public Health

基　　金：国家自然科学基金重点项目资助 (编号 5983830 0 )

摘　　要：目的　观察长期饮用纯净水后大鼠心脏及肾脏相关临床指标的改变 ,并与饮用传统自来水的大鼠比较。方法　Wistar大鼠自出生前 2周就分别给予纯净水及自来水 ,直至出生后 2 0周。实验结束时观察体重 ,心肾器官重量 ,血液学指标 ,相关的临床生物化学指标以及心肾脏器的组织病理学改变。结果　与同性别饮用自来水的大鼠相比较 ,饮用纯净水的大鼠雄性平均体重明显增加 (P <0 0 5) ,雌性血中甘油三酯及胆固醇水平明显增加 (两者P <0 0 5) ;同时雄性血中肌酐和尿素氮明显下降 (两者P <0 0 1 ) ,血尿酸和磷水平下降 (两者P <0 0 5) ,雌性血磷水平有明显下降(P <0 0 5)。另外 ,在纯净水组大鼠发现心肌细胞病变及肾小管透明管型改变。结论　与饮用自来水比较 。Objective To compare clinical parameter differences in heart and kidney between rats drinking purified water and boiled tap water.Methods Wistar rats before their born were supplied with purified water and boiled tap water respectively for 20 weeks.Rats were sacrificed at the end of the experiment.Body weight,organ weight of heart and kidney,hematological parameters,related clinical biochemistry parameters,and histopathological changes of heart and kidney organs were observed.Results Compared with the same sex rats that dank boiled tap water,the male's mean body weight significantly increased ( P <0 05),and the female's blood triacylglycerol and cholesterol significantly increased (both P <0\^05).Concomitantly,blood plasma creatinine and urea nitrogen decreased very significantly( P< 0\^01),and urea acid and phosphers decreased significantly( P <0\^05)for males,but only urea acid decreased significantly( P< 0\^05)for females.In additional,slightly pathological changes in myocardial cell and typical hyaline cast in kidney tubules were observed in the rats that drank bottled purified water.In contrast,the rats given boiled tap water showed no such variation.Conclusion Long term intake of purified water can cause biological effects on heart and kidney.

关 键 词：纯净水 心脏 肾脏 血液学 组织病理学 

分 类 号：R123[医药卫生—环境卫生学]