化疗所致粒细胞缺乏症患者医院感染危险因素的多因素Cox模型分析  

Cox Proportion Hazard Model Multivariate Analysis on Risk Factors of Hospital Infection in Patients with Agranulocytosis Induced by Chemotherapy

作　　者：程伏林[1] 胡名柏[1] 袁宏银[1] 魏正专[1] 白德骄[1] 

机构地区：[1]武汉大学中南医院肿瘤研究所,湖北武汉430070

出　　处：《中华医院感染学杂志》2002年第5期327-328,共2页Chinese Journal of Nosocomiology

摘　　要：目的　预测化疗所致粒细胞缺乏症患者医院感染发生的危险因素。方法　对 345例因化疗所致粒细胞缺乏症患者医院感染进行回顾性调查 ,用多因素 Cox模型分析 16个可能对医院感染产生影响的危险因素。结果　年龄、粒细胞缺乏程度、低粒细胞持续时间、化疗周期和预防使用粒细胞集落刺激因子 (CSF)对医院感染的发生有显著意义 (P<0 .0 5 )。结论　对高危患者应采取积极有效的预防措施 。OBJECTIVE To predict the risk factors of hospital infection in patients with agranulocytosis induced by chemotherapy.METHODS The data were analyzed in 345 patients with agranulocytosis induced by chemotherapy. Sixteen individual variables were evaluated statistically using the infection rate by the computer′s Cox multivariate analysis model.RESULTS Multivariate analysis showed that the age, degree and duration of agranulocytosis,chemotherapy period and granulocyte colony stimulating factor were significantly independent risk factors.These factors were put together to construct a risk index formula.CONCLUSIONS Positive measures should be taken to prevent hospital infection of high risk group patients.

关 键 词：危险因素 COX模型 化学治疗 粒细胞缺乏症 医院感染 

分 类 号：R181.34[医药卫生—流行病学] R557.3[医药卫生—公共卫生与预防医学]