普乐林注射液对戊巴比妥钠催眠作用的影响  

Influence of puerarin on the hypnotic effect of pentobarbital sodium in mice

作　　者：王德才[1] 黄东军[2] 高允生[1] 朱玉云[1] 李娟[1] 史以菊[1] 

机构地区：[1]泰山医学院药学系,山东泰安271000 [2]泰安市岱岳区妇幼保健院,山东泰安271000

出　　处：《泰山医学院学报》2002年第1期18-19,共2页Journal of Taishan Medical College

摘　　要：目的　观察普乐林 (PRN)对小鼠戊巴比妥钠催眠作用的影响。方法　将 12 0只小鼠随机分为生理盐水组、苯巴比妥 (40mg kg)组、PRN (5 0、15 0mg kg)组 ,腹腔注射 ,每日 1次× 7d。第 8d腹腔注射戊巴比妥钠 75mg kg ,观察催眠潜伏期及催眠时间。结果　苯巴比妥、5 0和 15 0mg kgPRN分别使催眠时间缩短 87 7% (P <0 0 1)、2 5 8% (P <0 0 5 )和 5 3 3% (P <0 0 1)。各组小鼠催眠潜伏期无显著性差异。结论　PRN能显著缩短戊巴比妥钠对小鼠的催眠时间 ,提示PRN能诱导小鼠肝微粒体细胞色素P4 5Objective: To observe the influence of puerarin (PRN) on the effect of pentobarbital sodium in mice. Methods: 120 mice were randomly divided into normal saline, Phenobarbital(40 mg/kg) and PRN (50,150 mg/kg) groups, which were administered intraperitoneally (ip) once daily for seven days. All the animals were given pentobarbital sodium (75 mg/kg, ip) at the eighth day, and then the incubation and duration of hypnosis were obsorved. Results: Hypnotic duration was shortened by 87.7% (P<0.01), 25.8% (P<0.05)and 53.3% (P<0.01) in the phenobarbital, 50 and 150 mg/kg PRN groups respectively. All the groups had no significant differences in the hypnotic incubation. Conclusion: PRN can obviously shorten hypnotic duration of pentobarbital sodium, which suggests that PRN could induce liver microsomal cytochrome P450 in mice.

关 键 词：普乐林 戊巴比妥钠 催眠作用 细胞色素P450 

分 类 号：R285.5[医药卫生—中药学]