羧乙基锗倍半氧化物(Ge-132)在大鼠乙醇中毒过程中的抗氧化作用  

Antioxidative ability of carboxyethylgermanium (Ge-132) on the alcoholism in rat

作　　者：周颖 石同幸 聂木海 诸茂盛 麦惠霞 

机构地区：[1]广州市卫生防疫站毒理科,广州510080

出　　处：《热带医学杂志》2002年第1期43-45,共3页Journal of Tropical Medicine

摘　　要：目的　探讨羧乙基锗倍半氧化物 (Ge 132 )在乙醇致体内脂质过氧化过程的抑制作用及机理。方法用 10mg/kg体重的乙醇给大鼠灌胃 ,同时自由饮用 10 0mg/L的锗 132 ,饲养 3个月。 结果　乙醇 +Ge 132组大鼠组织和血清与单给乙醇组比较MDA含量显著降低 (P <0 .0 5 ) ,SOD、CAT活力均升高 (P <0 .0 5 ) ,但与对照组比较均无显著性差异 (P >0 .0 5 )。结论　Ge 132通过清除OH·和O2 ·-自由基 ,抑制SOD、CAT活力降低 。Objective To study the mechanism of the inhibition of lipid peroxidation caused by alcohol in vivo by carboxyethylgermanium (Ge-132).Methods SD rats were orally fed with alcohol at the dose of 10mg/kg, and Ge-132 at the dose of 100mg/L at the same time for three months.Results Results indicated that the contents of malondialdehyde (MDA) was decreased (P<0.05) and the activities of superoxide dismutase(SOD), catalase(CAT) were increased in tissues and sera of the rats treated with alcohol+Ge-132 when compared with those treated with alcohol only (P<0.05), but showed no significant differences when compared with untreated rats (P<0.05).Conclusion The result indicated that the Ge-132 could reduce the harmful effect of over-dose alcohol to the animal by scavenging hydroxyl radical(OH·) and superoxide anion radical(O 2· -) through up regulating the activities of SOD and CAT.

关 键 词：羧乙基锗倍半氧化物 乙醇 脂质过氧化 毒理学 

分 类 号：R992[医药卫生—毒理学]