烧伤后多系统脏器衰竭患者血浆AⅡ、ANP、AⅡ/ANP水平及临床意义  

Clinical study of plasma angiotensin Ⅱ(AII),atrial natriuretic peptide(ANP) and AII/ANP ratio in postburn multiple organ failure (MOF)

作　　者：刘德贵[1] 杨宗城[2] 杨勇[1] 程崇碘 李晋[1] 王红梅[1] 

机构地区：[1]成都军区总医院烧伤整形科,成都610083 [2]第三军医大学西南医院烧伤研究所,重庆400038

出　　处：《西南国防医药》2002年第1期10-13,共4页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的 :对烧伤面积 (TBSA) >2 0 %患者 5 9例 (其中单脏器功能衰竭 6例 ,多脏器功能衰竭 14例 )进行前瞻性临床研究。方法 :连续测定了血浆血管紧张素Ⅱ (AⅡ )和心房肽 (ANP)及血N -乙酰 - β -D -氨基葡萄糖苷酶 (NAG)活性 ,以探讨AⅡ /ANP失衡在严重烧伤后多脏器衰竭中的作用。结果 :严重烧伤后存在着AⅡ /ANP明显失衡 ,与烧伤严重程度、低血容量休克、全身性感染有关。MOF患者AⅡ /ANP显著高于non -MOF者 ,AⅡ /ANP与NAG活性呈显著正相关。结论 :AⅡ /ANP在MOF发生发展中起着重要作用。AⅡ /ANP及NAG也是反映烧伤后MOF病情及预后的重要参考指标。Plasma angiotensin Ⅱ(AII), atrial natriuretic peptide(ANP), and AII/ANP ratio and N-acetyl-β-D-glocosaminidase (NAG) in blood samples from burn patients were determined. The results demonstrated that AII, ANP, AII/ANP, NAG of these patients increased significantly. The increased level of AII/ANP correlated positively with the extent of burn injury, as well as the severity of post-burn multiple organs failure(MOF). Therefore it was suggested that the imbalance of AⅡ/ANP played an important role in the pathogenesis of post-burn MOF, and AII/ANP and NAG could be used to determine the severity of post-burn MOF and prognosis of severe burn patients.

关 键 词：烧伤 多系统脏器衰竭 患者 血浆 临床意义 血管紧张素Ⅱ 心房 NAG 

分 类 号：R644[医药卫生—外科学] R59[医药卫生—临床医学]