妊娠高血压综合征患者血浆神经肽Y与神经降压素的改变  

Changes of serum Neuropeptide Y and Neurotensin in patients with pregnancy-induced hypertension syndrome

作　　者：周媛[1] 刘永生[2] 薛惠容[1] 

机构地区：[1]中国人民解放军第222医院妇产科,吉林吉林132000 [2]中国人民解放军第222医院心血管内科,吉林吉林132000

出　　处：《吉林医学》2002年第2期67-68,共2页Jilin Medical Journal

摘　　要：目的 :探讨神经肽Y(NPY)、神经降压素 (NT)与妊娠高血压综合征发病的相关性。方法 :应用放免分析法同步测定轻、中、重度妊高征组各 30例及正常对照组 30人血浆NPY、NT的浓度 ,并测定妊高征患者及正常对照组胎盘娩出后即刻、第 7天、第 14天及第 2 1天血浆NPY、NT的浓度。结果 :妊高征患者较正常孕妇血浆NPY浓度高 ,与平均动脉压呈正相关。NT浓度较正常对照组低 ,与平均动脉压呈负相关。此组神经内分泌因子浓度的变化于产后 2周恢复正常。结论 :NPY与NT在血浆中浓度的变化对妊高征的病理生理过程具有重要的影响作用 ,并与妊高征的轻重程度密切相关。Objective To investigate the relationship between serum Neuropeptide Y(NPY) or Neurotensin(NT) levels and the incidence of pregnancy induced hypertension syndrome(PIH).Method The peripheral venous blood are collected from patients with different severity of PIH (slight,moderate and serious,30 individuals each) and 30 healthy controls,and in different periods (before delivery and immidiately,after 7 days,14 days,21 days of labor).Serum levels of NPY and NT are measured by radioimmunoassay.Results The serum NPY levels in PIH patients were higher than in healthy control group,and there was positive correlation between NPY levels and mean arterial pressure.The serum NT levels in PIH patients were lower than in healthy control group,and have negative correlation with mean arterial pressure.These two neuroendocrine factors would recover to the normal levels after two weeks of delivery.Conclusion NPY and NT had played important roles in the pathophysiological process of PIH,and might affect the severity of this disease.

关 键 词：妊娠高血压综合征 血浆 神经肽Y 神经降压素 

分 类 号：R714.246[医药卫生—妇产科学]