氨基糖苷类抗生素在儿科的不良反应及合理应用  

The application in reason and adverse reactions of aminoglycoside antibiotics in pediatric

作　　者：周基华[1] 

机构地区：[1]南京医科大学附属儿童医院,210008

出　　处：《儿科药学》2002年第2期8-11,共4页Journal of Pediatric Pharmacy

摘　　要：目的 :探讨氨基糖苷类抗生素不良反应的规律及特点。方法 :用文献计量方法对将近 10年国内公开报道的此类抗生素所致的不良反应进行分析。结果 :其严重不量反应肾损害占 5 2 6 3% ,其它不良反应也占一定比例 ,不容忽视。结论 :氨基糖苷类抗生素的耳肾毒性易在儿科患者发生 ,尤其对婴幼儿危害性最大 ,严重者可终身致残废 ,肾损害严重者可致死亡 。Objective:To access the characteristics and regularity of ADR on aminoglycoside Methods:To analyzed the domestic reports about aminoglycoside's adverse reaction within 10 years in document counts methods Results:The proportion of badly reaction nephrotoxicity count up to 52 63% and others in ADR were found too Conclusions: Ototoxicity and nephrotoxicity in aminoglycoside's ADR were found in Pediatrics easily,espeacialy in infants And some most serious reaction led to disabled and death So aminoglycoside should be use under supervision

关 键 词：氨基糖苷类抗生素 儿科 药物不良反应 合理用药 

分 类 号：R978.12[医药卫生—药品] R985[医药卫生—药学]