小儿β-内酰胺类抗生素相关性腹泻85例分析  

Analysis of 85 cases of diarrhed associated with β-lactam antibiotic

作　　者：王明月[1] 沈德炜[1] 刘健[1] 牟春笋[1] 吕素华[1] 

机构地区：[1]济南铁路局中心医院,济南250001

出　　处：《儿科药学》2002年第2期56-57,共2页Journal of Pediatric Pharmacy

摘　　要：目的 :了解β 内酰胺类抗生素导致抗生素相关性腹泻 (AAD)的发病情况。方法 :调查儿科住院患儿在应用抗生素过程中AAD的发病率、临床表现、实验室检查。结果 :β 内酰胺类抗生素致AAD 85例 ,其中由第三代头孢菌素所致 5 5例 (6 4 7% ) ,第一代头孢菌素与广谱青霉素次之。各组AAD发病时间、腹泻次数均有统计学差异。结论 :β 内酰胺类抗生素导致AAD较常见 ,其中第三代头孢菌素所致AAD的腹泻程度重于青霉素类及第一代头孢菌素引起的AAD。Objective:To study on antibiotic associated diarrhea(AAD) Methods:to investigate the incidence,clinical manifestion,laboratory tests of AAD of inpatient children with antibiotic therapy Results:85 Cases of AAD are caused by β lactam antibiotic,of which there are 55 cases by the third generation of cephalosporin,28cases by the first generation of cephalosporin and broad spectrum penicillinum,and 2 cases by narrow spectrum penicillinum,and the attack time and diarrhea times in each AAD group have statistical difference Conclusion:AAD caused by β lactam antibiotic are common,and the diarrhea degree caused by the third generation of cephalosporin is serious than that by penicillinum and the first generation of cephalosporin

关 键 词：小儿 β-内酰胺类抗生素相关性腹泻 Β-内酰胺类抗生素 腹泻 药物不良反应 

分 类 号：R978.11[医药卫生—药品] R574.62[医药卫生—药学]