胰高血糖素受体基因多态性与2型糖尿病相关性研究  

Study in the association between glucagon receptor gene polymorphism and type 2 diabetes mellitus

作　　者：王国英[1] 李琼芳[1] 邓正照[1] 洪天配[1] 王艳荣[1] 张路[1] 马征[1] 王群[1] 

机构地区：[1]北京大学第三医院内分泌科,100083

出　　处：《北京医学》2002年第3期147-149,共3页Beijing Medical Journal

摘　　要：目的　探讨中国汉族人群中胰高血糖素受体 (GCGR)基因Gly4 0Ser多态性与 2型糖尿病的相关性。方法　采用聚合酶链反应 寡核苷酸连接测定方法 ,对北京地区 10 2对病例 对照配偶对进行GCGR基因Gly4 0Ser多态性基因型检测。结果　病例组和对照组共 2 0 4例样本中均未发现GCGR基因Gly4 0Ser突变。 结论　在中国汉族人群中GCGR基因Gly4 0Ser多态性对 2型糖尿病的发生可能影响不大。Objective To study the relationship between the polymorphism at codon 40 of glucagon receptor gene (GCGR) polymorphism with type 2 diabetes mellitus in Chinese Han population.Methods To evaluate the polymorphism by the polymerase chain reaction(PCR) oligonucleotide ligation assay in 102 pairs case-control spouses in Beijing district.Results None of the 204 Chinese subjects had this mutation.Conclusions GCGR gene seems to play little role in the pathogenesis of type 2 diabetes in Chinese Han population.

关 键 词：胰高血糖素 基因多态性 胰高血糖受体 2型糖尿病 聚合酶链反应-寡核苷酸连接测定法 胰高血糖受体基因 

分 类 号：R587.1[医药卫生—内分泌]