半夏泻心汤不同配伍情况下部分化学成分变化  

The Changes of Some Chemical components in Banxiaxiexintang Decoction of Different Combinations

作　　者：段天璇[1] 马长华[1] 侯艳霞[1] 刘舒萍[1] 陈韬[1] 伦丽辉[1] 小熊亮子[1] 李宇航[1] 

机构地区：[1]北京中医药大学中药学院,北京100029

出　　处：《中国中药杂志》2002年第5期363-365,共3页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金资助项目 (3 9870 95 0 )

摘　　要：目的 :测定半夏泻心汤不同配伍情况下小檗碱、巴马丁及甘草酸的含量。方法 :复方按药物性味分组 ,高效液相色谱法测定。结果和结论 :不同组合中小檗碱、巴马丁及甘草酸的煎出量不同 。Objective:The contents of bererine, palmatine and glycyrrhizin acid in Banxiaxiexintang decoction of different combinations were determined by PR HPLC.Method:A Shim pack CLC ODS column was used with a mobile phase of CH 3CN H 2O (31∶69;0.005 moL·L -1 pentanesulfonic acid sodium salt, H 3PO 4: pH 3.0) for bererine andpalmatine, which were detected at the wavelength of 275 nm. A YWG C 18 column was used with a mobile phase of CH 3OH H 2O HAc(62∶37∶1) for glycyrrhizin acid which was detected at the wavelength of 260 nm.Result:each herbs' combination influences the contents of the 3 components.Conclusion:The experiment is an attempt to study the comical foundation of traditional Chinese prescription.

关 键 词：半夏泻心汤 小檗碱 巴马丁 甘草酸 高效液相色谱法 配伍 

分 类 号：R289.5[医药卫生—方剂学]