维生素对大鼠脂质及脂质过氧化作用的影响  

Influences of vitamins on Lipids and Lipid peroxidafion in rats

作　　者：周延升[1] 李聪辉[1] 李平法[1] 袁宇[2] 李素芬[2] 李西兴[1] 谷兆侠[1] 

机构地区：[1]新乡医学院生物化学教研室,河南新乡453003 [2]新乡医学院第一附属医院,河南卫辉453100

出　　处：《新乡医学院学报》2002年第2期81-83,共3页Journal of Xinxiang Medical University

基　　金：河南省科委自然科学基金资助项目 (96 12 0 0 6 11)

摘　　要：目的　探讨不同种类维生素对大鼠血浆胆固醇及脂质过氧化作用的影响。方法　各组大鼠均灌胃给予胆固醇乳化剂 ,并在饮水中加入 0 .5 %的蛋氨酸 ,同时各实验组分别给予相应维生素 ,对照组给予等量的生理盐水 ,连续 4周。用酶法和TBA荧光测定法分别检测血清胆固醇和脂过氧化物的水平。结果　维生素E、C、B6、B12 及叶酸单用或联用均能显著降低血清脂过氧化物的水平 ,其中维生素C、B6、B12 +叶酸还有降低血清胆固醇的作用。Objetive To study the influences of various vitamins on serum cholesterol and lipidperoxidation in rats.Methods The rats with hypercholesterolemia and methionine load were fed with either various vitamins as experimental groups or physiological saline as the control group for 4 weeks. The levels of plasma cholesterol and lipoperoxides were detected by enzymic method and TBA fluorometry Results The levels of plasma lipoperoxides decreased significantly in vitami E,C,B 6 and B 12 alone and plus folacin groups. The levels of plasma cholesterol also decreased significantly in vitamin C, B 6 and B 12 alone and plus folacin groups.Conclusion The vitamins supplementation can be play a certain role in resolusion of atherosclerosis risk factosr,and it may be favourable for preventing atherosclerosis initiation and development.

关 键 词：维生素 脂类 胆固醇 脂过氧化物 动脉粥样硬化 

分 类 号：R977.2[医药卫生—药品] R965[医药卫生—药学]