益气通络丹对冠心病病人红细胞过氧化反应及红细胞变形性的影响  

Effects of Yi Qi Tong Luo Dan on blood peroxide reaction and erythrocyte deformabiloity in coronary heart disease

作　　者：赵锦程[1] 庾英兰 韩玉泽[1] 田春时[1] 

机构地区：[1]佳木斯大学基础医学院,黑龙江佳木斯154002 [2]佳木斯市中心医院

出　　处：《黑龙江医药科学》2002年第3期30-31,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的和方法:本实验检测了41例冠心病病人使用益气通络丹治疗前后循环血中红细胞超氧化物歧化酶(SOD)活力;全血谷胱苷肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)活力;血浆总抗氧化能力(AOA);红细胞膜丙二醛(MDA)含量;红细胞滤过指数(IF)的变化。结果:治疗前红细胞SOD、全血GSH-Px、CAT活力、血浆AOA明显下降(P<0.05),红细胞膜MDA含量明显升高(P<0.05),红细胞IF明显升高(P<0.01)。治疗后与治疗前比较,红细胞SOD、全血GSH-Px、CAT活力、血浆AOA明显升高(P<0.01),红细胞膜MDA含量明显降低(P<0.01),红细胞IF明显降低(P<0.01)。结论:益气通络丹能减轻病人血液过氧化反应,改善红细胞变形性(ED)。Objective: In order to study the effect of Yi Qi Tong Luo Dan (YQTLD) on the blood peroxydation and erythrocyte defomability(ED) in coronary heart disease(CHD). Methods: The superoxide dismutase(SOD)vitality of erythrocyte, glutathione peroxidase (GSH-Px), cataiase (CAT) vitality of the whole blood, antioxidite ability(AOA) of plasma, molondialehyde (MDA) concent of erythrocyte membrane and erythrocyte filtration(IF) were measured in the patients with CHD before and after treatment using YQTLD. Results: The SOD vitality of erythrocyte, GSH-Px, CAT vitality of the whole blood, and AOA of plasma were much lower than those of the control(P<0.05, P<0.01),the MDA concent of erythrocyte membrane and erythrocyte IF were much higher than those of control(P<0.01).After treatment with YQTLD the SOD vitality of erythrocyte,GSH-Px,CAT vitality of blood, and AOA of plasma were significantly higher than those of the group before treatment(P<0.05), the MDA concent of erythrocyte membraneand erythrocyte IF were much lower, as compared with the group before treatment (P<0.05, P<0.01). Conclusion: YQTLD can reduce the peroxide reaction and enchance ED.

关 键 词：益气通络丹 冠心病 病人 红细胞 过氧化反应 红细胞变形性 

分 类 号：R259.414[医药卫生—中西医结合]