多巴胺在聚异烟酸修饰玻碳电极上的电化学行为  

ELECTROCHEMICAL BEHAVIOR OF DOPAMINE AT THE POLY (ISONICOTINIC ACID) MODIFIED GLASSY CARBON ELECTRODE

作　　者：赵红[1] 张玉忠[1] 袁倬斌[1] 

机构地区：[1]中国科学技术大学研究生院,北京100039

出　　处：《药学学报》2002年第6期454-457,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目 ( 2 9875 0 2 7) ;中国科学院长春应用化学研究所电分析化学开放研究实验室基金资助项目 (OC2 0 0 0 1) .

摘　　要：目的　在抗坏血酸 (AA)存在下 ,用聚异烟酸修饰电极测定神经递质多巴胺 (DA)。方法　用循环伏安法和示差脉冲伏安法研究DA在聚异烟酸膜修饰电极上的伏安行为。结果　聚异烟酸膜修饰电极对DA有明显的电催化作用。该修饰电极使AA的氧化峰电位负移 ,与DA氧化峰电位分开达 2 0 4mV ,从而消除了对DA测定的干扰。DA在该修饰电极上的氧化峰电流与其浓度在 1 0× 10 - 7～ 2 0× 10 - 5和 2 0× 10 - 5～ 1 0× 10 - 4mol·L- 1 呈良好线性关系 ;检测限为 8 0× 10 - 9mol·L- 1 。结论　聚异烟酸膜修饰电极使用寿命至少 3周 。AIM To study the determination of dopamine (DA) in the presence of ascobic acid (AA) using poly (isonicotinic acid) film modified electrode. METHODS The cyclic voltammetry and differential pulse voltammetry were used to study the electrochemical behavior of DA at the poly (isonicotinic acid) film modified electrode. RESULTS The poly (isonicotinic acid) film modified electrode showed an electrocatalytic effect on DA, and shifted the oxidation of AA to negative potential. The difference between the oxidation potentials of DA and AA was 204 mV, thus,AA did not interfere with the determination of DA. The linear range between the anodic currents and DA concentration was: 1 0×10 -7 ～2 0×10 -5 and 2 0×10 -5 ～1 0×10 -4 mol·L -1 . The detection limit was 8 0×10 -9 mol·L -1 . CONCLUSION The useful life period of the modified electrode is three weeks at least. The modified electrode can be used to the determination of DA in the sample.

关 键 词：多巴胺 聚异烟酸修饰电极 伏安法 抗坏血酸 电化学 神经递质 

分 类 号：TQ460.72[医药卫生—药物分析学]