^(13)C-尿素呼吸试验对儿童幽门螺杆菌感染根除后1年的随访  

One year follow-up by ^(13) C-urea breath test after successful helicobacter pylori eradication in children

作　　者：项立[1] 文飞球[1] 唐沂[1] 卓卫华[1] 李玉华[1] 吴本清[1] 刘智屏[1] 李国锋[1] 陈霆[1] 贺务实[1] 

机构地区：[1]暨南大学医学院第二附属医院儿科,深圳518020

出　　处：《实用儿科临床杂志》2002年第3期180-181,共2页Journal of Applied Clinical Pediatrics

基　　金：广东省卫生厅名义立项;深圳市卫生局匹配基金资助 (项目编号:199814 8)

摘　　要：目的　探讨洛赛克、克拉霉素、阿莫西林三联根除儿童幽门螺杆菌 (Hp)感染的远近期疗效。 方法　经1 3C尿素呼吸试验 (1 3C UBT)及血清Hp IgG测定 2项阳性的反复腹痛儿 95例 ,随机分为治疗组 (60例 )与安慰剂组 (35例 ) ,治疗组接受洛赛克 0 .8mg/ (kg·d) ,每天一次 ,克拉霉素 1 5mg/ (kg·d) ,每天 2次 ,阿莫西林 30mg/ (kg·d) ,每天 3次 ,三联口服治疗 ;疗程 1周。停药后 1 ,3 ,6 ,1 2个月门诊随访 ,复查1 3C UBT及Hp IgG。 结果　 1 .治疗组停药后 4周腹痛的总有效率 96 .7% ,而安慰剂组仅 34 .6 % ;治疗组Hp根除率为 90 % ,明显高于安慰剂组 1 4 .3 %。 2 .治疗组Hp根除后 3 ,6 ,1 2个月复查Hp再感染率分别为 1 .85 %、1 .85 %、3 .57%。 结论　 1 .洛赛克等三联根除反复腹痛儿Hp感染临床效果显著 ,Hp根除率高 ,远近期疗效均好 ,1年再感染率低。2 .1 3C UBT监测Hp根除情况快捷准确。Objective To investigate short and long term efficacy of Losec,Clarithramycin ,Aomxillin triple therapy for eradicating Helicobacter pylori(Hp) infection in children.Methods Children with recurrent abdominal pain ,whose Hp infection was identified by both 13 C UBT and Hp IgG, were divided into the study group and placebo control group . The study group were given Losec,Clarithramycin ,Amoxillin triple therapy. The whole course was one week. They were followed up at the interval of 1 month, 3 months, 6 or 12 months respectively after stopping taking the medicine.Results The total effective rate of the therapy was 96.7 % in the study group , while 34.6 % in placebo group. The Hp eradication rate was 90 %, which was much higher than that of placebo group(14.3 %). The Hp reinfection rate was 1.85 %, 1.85 %, 3.57 % respectively in 3, 6 or 12 months after Hp eradication.Conclusions This therapy is very effective clinically and has a high Hp eradication rate ,and have good short and long term efficacy with Losec triple therapy for eradicating Hp infection in children. The reinfection rate is very low within one year.It is fast and accurate for 13 C UBT to monitor Hp eradication.

关 键 词：洛赛克 克拉霉素 阿莫西林 HP根除率 ^13C-尿素呼吸试验 儿童 幽门螺杆菌 

分 类 号：R817.4[医药卫生—影像医学与核医学]