不同免疫抑制剂联合雄激素治疗儿童重型再生障碍性贫血  

Immunosuppitssive agents combining with stunozolol for treatment of severe aplastic anamia in children

作　　者：陈力军[1] 张太娥[1] 欧阳士香[1] 

机构地区：[1]山东省立医院,山东济南250021

出　　处：《山东医药》2002年第10期3-5,共3页Shandong Medical Journal

摘　　要：22例重型再生障碍性贫血 (SAA)患儿分为三组 ,分别应用环孢菌素 A(CSA) +康力龙、大剂量丙种球蛋白 (HDIG) + CSA+康力龙、抗胸腺细胞球蛋白 (ATG) + CSA+ HDIG+康力龙进行治疗观察 ,对比各方案近、远期疗效。结果 :2 2例患儿经治疗后随访 6个月～ 6年 ,18例存活 ,近期总有效率为 81.8% (18/ 2 2 )。各方案疗效对比 ,方案 优于方案 及 ;而可评定远期疗效的 10例患儿其总有效率为 70 % (7/ 10 ) ,各方案疗效则为方案 优于方案 及 。认为 :方案 疗效安全、可靠、有效 ,但起效慢 ;方案 疗效虽高 ,但 ATG所致血清病反应较重 ,尤影响近期疗效 ,且花费较大 ;方案 疗效肯定 ,起效快 ,无严重不良反应 ,较经济 。To investigate the therapeutic effectiveness of immunosuppressive agents combining with stanozolol in treating severe aplastic anemia(SAA)for children, three regimens were cyclosporine A(CSA)+stanozolol, high dose immunoglobulin (HDIG)+CSA+stanozolol and antithymocyte globulin(ATG)+CSA+HDIG+stanozolol. 22 cases were treated and followed on 6 months to 6 years. The therapeutic effectiveness of the regimens was observed and compared with each other. 18 cases were survived. The regimen Ⅱ was better than regimen Ⅰor Ⅲ for the whole short term efficiency 81.8% (18/22). Regimen Ⅲ was better than regimen Ⅰor Ⅱfor the whole long term efficiency 70%(7/10) in the 10 children who were able to be evaluated. Regimen Ⅰ was safe, dependable, effective, but it's effect was shown slowly. Regimen Ⅲ had significant effect, but the serious seroanphylaxis caused by ATG can affect the shor term effectiveness,and the cost of therapy was much. Both the long and short term effectiveness of regimen Ⅱ were safe dependable and significant. Regimen Ⅱ was the optimal regimen in treating severe aplastic anemia for children.

关 键 词：雄激素 儿童 重型再生障碍性贫血 不良反应 免疫抑制剂 SAA 治疗方案 

分 类 号：R725.565[医药卫生—儿科] R979.5[医药卫生—临床医学]