超顺磁性氧化铁胶束体系的制备和T_2弛豫增强作用  

PREPARATION AND NEGATIVE MRI SPIN-SPIN RELAXATION ENHANCEMENT OF SUPERPARAMAGNETIC IRON OXIDES

作　　者：俞开潮[1] 张焱[1] 杨运煌[2] 卢广[2] 刘买利 叶朝辉 

机构地区：[1]华中科技大学化学系,湖北武汉430074 [2]中国科学院武汉物理与数学研究所波谱与原子分子物理国家重点实验室,湖北武汉430071

出　　处：《波谱学杂志》2002年第2期143-148,共6页Chinese Journal of Magnetic Resonance

基　　金：国家杰出青年基金 (2 992 5 5 1 5 );湖北省自然科学基金 (99J0 67);波谱与原子分子物理国家重点实验室开放基金资助

摘　　要：制备了在负离子型胶束十二烷基硫酸钠 (SDS)、羧甲基纤维素钠 (CMC) ,正离子型胶束十六烷基三甲基溴化铵 (CTAB)和非离子型胶束TritonX 1 0 0、PEG 40 0中的氧化铁粒子(SPIO)溶胶分散体系 .测定了这些SPIO胶束体系水质子的横向弛豫时间T2 ,并讨论了不同胶束性质对T2 的影响 .对PEG 40 0分散SPIO溶胶体系进行了动物急性毒性测试和活体T2加权成像实验 .结果表明 :该溶胶体系无明显急性毒性 。Superparamagnetic iron oxides (SPIO) are known for their fast T\-2 (T\+*\-2) relaxation properties which result in a strong decrease in signal intensity (negative enhancement) of such reticuloendothelial system as the liver, the spleen, and et al where they accumulate. For its low solubility in water, SPIO usually are colloidally coated and stabilized with a matrix such as dextran or liposomes. In this work, a series of micelle coated and stabilized SPIO colloids were prepared and the T\-2 values of these SPIO micells were measured, aiming to investigate the effect of properties of different micelles on SPIO solution. The experimental data showed that both different kind of charge which the micelle has and the molecular weight of surfactant have distinct effect on the T\-2 relaxation of SPIO colloid. The SPIO colloid coated by PEG 400 was selected for the acute toxicity and MR imaging contrast test. The results indicated that there was no obvious toxicity for this polymeric micelle coated SPIO colloid, and mini dose (20 μmol/kg) of SPIO exhibits the obvious negative enhanced MRI signal intensity in the rat liver tissue.

关 键 词：超顺磁性氧化铁-胶束体系 制备 T2驰豫增强 肝靶向造影 T2加权磁共振成像 负增强 造影剂 临床诊断 

分 类 号：R445.2[医药卫生—影像医学与核医学]