加味温胆汤对SAM-P/10老化痴呆鼠三个脑区抑制性氨基酸的影响  

Effect of Xinnao Yizhi prescription on IAAs in brain hippocampi, cortex and striate body of SAM-P/10 mice.

作　　者：王平[1] 刘玲[1] 张六通[1] 邱幸凡[1] 

机构地区：[1]湖北中医学院老年医学研究所

出　　处：《华中医学杂志》2002年第3期125-127,共3页Central China Medical Journal

基　　金：湖北省自然科学基金重点资助项目 (No.99J0 86)

摘　　要：目的　探讨中药加味温胆汤改善脑功能的中枢机制。方法　采用高效液相技术系统观察SAM P/ 10鼠脑内皮层、海马、纹状体等与学习记忆关系密切的脑内 4种氨基酸水平的变化。结果　加味温胆汤 1号方对于海马、纹状体异常升高的γ 氨基丁酸 (γ GABA)水平表现出明显降低作用 ;加味温胆汤预防方对皮层降低的牛磺酸 (Tau)水平有明显的升高作用(P <0 .0 1) ,1号方亦有明显升高作用 (P <0 .0 5 ) ,2号方和西药组仅表现上升趋势。结论　加味温胆汤对于快速老化的SAM P/Objective To explore the center mechanism that Xinnao Yizhi prescription improves the function of brain.Methods By using high performance liquid chromatography the change of 8 amino acids closely relative with learning memory was observed in brain hippocampi, cortex and striate body of SAM P/10 mice.Results The prescription No.I could drop the level of abnormal increased r GABA obviously in hippocampi and striate body ( P < 0.01 or 0.05 ). The preventing prescription and prescription NO. I could markedly increase the decreased Tau level in cortex ( P < 0.01 , and P < 0.05 , respectively). Both the prescription No. Ⅱ and western medicine only showed an increased tendency.Conclusion Xinnao Yizhi prescription can regulate the levels of EAAs and IAAs obviously in SAM P/10 mice.

关 键 词：老化痴呆 动物模型 加味温胆汤 氨基酸 药理学 

分 类 号：R277.7[医药卫生—中医学]