2[对-(二甲氨基)苯乙烯]碘化甲基吡啶对细胞的致变性观察  

An Observation on Mutagenicity of DSPM to Mammalian Cells

作　　者：赵荣枝[1] 李牧尧[1] 刘宏戈 王越[1] 马梅荪[1] 张克锦[2] 周承明[2] 王晓雯[2] 

机构地区：[1]新疆医学院生物学教研室 [2]新疆医学院药理学教研室

出　　处：《新疆医学院学报》1991年第1期1-4,共4页

摘　　要：2[对-(二甲氨基)苯乙烯]碘化甲基吡啶(简称DSPM)是一种新发现的钙扩抗剂,有明显的临床价值。本文应用细胞遗传学方法,检测该药对人体外周血淋巴细胞和哺乳类离体细胞有丝分裂指数的影响,并在此基础上,检测了对哺乳类离体细胞染色体畸变率和小鼠骨髓嗜多染红细胞微核率的影响,为其安全性提供细胞遗传学资料。2[P-(dimethylamino) styzyl]pyridine methliodide (DSPM) is anewly discovered calcium antagonist. In this reports its effects on mitosis index of human peripheral lymphocytes, chromosomal aberration rate of grey hamster cell line (GH12A)and micronucleus forming rate of mouse polychromatic erythrocytes were observed. The results showed that DSPM over 10-~5M concentration, can restrict cell's growth but its cytotoxicity was getting lower with doses declining; while under three-group's concen-tration, the chromosomal aberration rate and micronucleus forming rate remained in safe range.

关 键 词：碘化甲基吡啶 染色体 畸变率 

分 类 号：R965.3[医药卫生—药理学]