血清抗脂阿拉伯甘露糖及38kD抗体检测对涂阴肺结核及肺外结核诊断价值  

Detection of lipoarabinomannan-38kD-IgG in serum for the diagnosis of pulmonary and extrapulmonary tuberculosis

作　　者：孔忠顺[1] 管波清[1] 古淑香[1] 马玙[1] 

机构地区：[1]北京市结核病胸部肿瘤研究所,北京101149

出　　处：《中国防痨杂志》2002年第3期140-142,共3页Chinese Journal of Antituberculosis

摘　　要：目的　评估血清抗脂阿拉伯甘露糖及 38kDa抗体 (LAM 38kD IgG)检测对涂阴肺结核和肺外结核的诊断价值。方法　采用斑点免疫金渗滤法 (dotimmunogoldfiltrationassay ,DIGFA)检测5 7例涂阴肺结核 ,5 2例肺外结核 ,32例涂阳肺结核 ,2 9例肺癌患者及 33例正常人血清中LAM 38kD IgG。 结果　涂阴肺结核组LAM 38kD IgG阳性率为 73.7% ,其中痰结核菌涂 (- )培 (+ )组为84 .6 % ,涂 (- )培 (- )组为 70 .5 %。肺外结核组阳性率为 71.2 % ,涂 (+ )肺结核组阳性率 93.8% ,肺癌组假阳性率 31% ,健康组假阳性率 9.1%。结论　血清LAM 38kDObjective To ascertain the value of lipoarabinomannan-38kD-IgG (LAM-38kD-IgG) determination in the diagnosis of smear negative pulmonary and extrapulmonary tuberculosis.Methods LAM-38kD-IgG in sera obtained from 57 patients with smear negative active pulmonary tuberculosis,52 patients with extrapumonary tuberculosis,32 patients smear positive pulmonary tuberculosis,29 patients with lung cancer and 33 healthy individuals were detected by dot immunogold filtration assay.Results The positive rate was 73.7% in smear negative pulmonary tuberculosis group and the positive rate was 71.2% in extrapulmonary tuberculosis group.The false positive rate was 31.0% in lung cancer group and 9.1% in healthy individuals group.Conclusion The results suggested that the LAM-38kD-IgG detection was a useful supplementary tool for the diagnosis of smear negative pulmonary tuberculosis and extrapulmonary tuberculosis.

关 键 词：肺结核 肺外结核 脂阿拉伯甘露糖 治疗 诊断 

分 类 号：R521[医药卫生—内科学]