吸食阿片类毒品对人体下丘脑-垂体-性腺轴及红细胞免疫功能的影响  

Effects of Drugs on the Addicts' hypo-pituitary-gonad axis and cellular immune function

作　　者：郭瑞林[1] 赵宁侠[1] 任秦有[1] 周建歧 史恒军[1] 侯颖[1] 

机构地区：[1]第四军医大学唐都医院中医科,陕西西安710038 [2]西安市公安局灞桥公安分局戒毒所,陕西西安710038

出　　处：《云南中医学院学报》2002年第2期18-20,共3页Journal of Yunnan University of Traditional Chinese Medicine

摘　　要：目的　研究吸食阿片类毒品对人体下丘脑 -垂体 -性腺轴及细胞免疫功能的影响。方法　应用酶免法检测LH、FSH、T的含量 ;应用红细胞C3b受体—酵母菌花环试验和红细胞 -IC花环试验检测红细胞免疫功能 ,应用流式细胞仪技术 ,通过微量全血直接免疫荧光染色法测定外周血T淋巴细胞亚群以反映细胞免疫功能并参考昆明药物依赖性康复中心《阿片类药物戒断症状量表》进行戒断肾阳虚损症状积分评定。结果　 17例吸毒者外周血检测后LH、FSH、T明显低于健康人 (P <0 0 0 1;P <0 0 1;P <0 0 5 ) ;C3b受体花环率 (RBC -C3bRR)、T4 细胞百分率 (CD4+ )明显低于健康人 (P <0 0 1) ;红细胞免疫复合物花环率 (RBC -ICR)及T8细胞百分率 (CD8+ )虽较健康人有不同程度的改变 ,但无统计意义 (P >0 0 5 ) ;而且依吸毒时间长短 ,日吸入量 ,个体等不同都有很大差异。戒断症状肾阳虚损积分评定 ,17例都有典型肾阳虚损症状。结论　吸毒者下丘脑 -垂体 -性腺轴功能障碍 ,提示 :吸食阿片类毒品可严重损害垂体性腺功能 ,毒品损伤肾经 ,引起肾阳虚损明显 ,细胞免疫功能低下 ,认定吸毒人员的中医证型是以肾阳虚损为主 ,为临床治疗提供科学依据。AIM To study the effects of drugs on addicts' hypo-pituitary-gonad axis and cellular immune function. METHODS The gonad's values (including FSH?LH and T)were observed to evaluate the gonad functions of the drugs addicts'.T-lymphocyte subgroups of peripheral blood(including CD 4 + and CD 8 +)were measured by direct microvolume whole blood immunoflurescent staining technique with flow cytometer (FCM) and erythrocyte immune functions (including RBC-C 3bRR and RBC-ICR) were observed to evaluate the immune functions in narcotic people. RESULTS The value of LH?FSH and T in the drug addicts were significantly lower than that in normal people (P<0 001; P<0 01;P<0 05);The value of RBC-C 3bRR, CD 4 + in the drug addicts was significantly lower than that in normal people (P<0 01);RBC-ICR was lower, CD + 8 was higher but RBC-ICR and CD + 8 were not significantly different from normal people (P>0 05). CONCLUSION The drugs addicts' hypo-pituitary-gondad axis function and cellular immune function were lower than that in normal people.

关 键 词：吸毒者 性腺检测 细胞免疫 肾阳虚损 

分 类 号：R595.5[医药卫生—内科学]