不同剂量valsartan应用对SHR血压和左室心肌肥厚的影响(英文)  

Effect of different doses of valsartan on blood pressure and left ventricular hypertrophy in spontaneously hypertensive rats

作　　者：汤海[1] 胡作英[2] 杨霆[3] 

机构地区：[1]南京医科大学,南京210009 [2]南京医科大学附属南京第一医院 [3]皖南医学院弋矶山医院

出　　处：《中国临床药理学与治疗学》2001年第1期12-14,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的评价不同剂量AT1 受体拮抗剂valsartan对SHR的降压疗效及其逆转心肌肥厚作用的影响。方法18只14周龄雄性SHR随机分成空白对照组、小剂量valsartan组、大剂量valsartan组 ,另设WKY正常对照组 ,分别给予生理盐水、valsartan8mg·kg-1、valsartan24mg·kg-1,每日1次灌胃给药 ,持续8wk。结果药物干预各组SHR动脉收缩压(SBP)水平明显下降 ,尤以大剂量valsartan组SBP下降最显著 ;药物干预各组LVM/BW、TDM均明显减低。结论不同剂量AT1 拮抗剂均有明显的降低SHR的SBP作用 ,能明显抑制左室肥厚进展 ;Aim To evaluate the effects of different doses of valsartan on blood pressure and left ventricular hypertrophy in spontaneously hypertensive rats (SHR).Methods Eighteen SHR (fourteen_ week_old, male) were divided into three groups (six rats in each group ): SHR control group in which the rats were fed with normal saline; low dose valsartan group in which the rats were fed with valsartan 8 mg·kg-1·d-1 and high dose valsartan group in which the rats were fed with valsartan 24 mg·kg-1·d-1, all for 8 weeks. The rats in the WKY control group (n=6)were fed with normal saline for 8 weeks.Results SBP, LVM/BW and TDM of SHR were remarkably lower than those of the control after drug intervention, and the effect on SBP, LVM/BW and TDM was most remarkable in the high dose valsartan group.Conclusion Different doses of valsartan can decrease SBP of SHR and inhibit the progression of ventricular hypertrophy.

关 键 词：高血压 自发性高血压大鼠 缬沙坦 左室心肌肥厚 

分 类 号：R972.4[医药卫生—药品]