阿司匹林、维拉帕米单用和合用对大鼠肠系膜微循环的影响  

Effects of aspirin and verapamil alone or in combination on mesentericmicrocirculation of rats

作　　者：宋益民[1] 李学坤[1] 谭建民[2] 李增唏[2] 石山[2] 

机构地区：[1]山东潍坊医学院药理学教研室,潍坊261042 [2]包头医学院心血管研究室,包头014010

出　　处：《中国临床药理学与治疗学》2001年第1期31-34,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金资助课题 (№38960058)

摘　　要：目的研究阿司匹林(Asp)与维拉帕米(Ver)合用对大鼠肠系膜微循环的影响。方法右旋糖酐(Mr480000)360mg·kg-1iv制备大鼠肠系膜急性微循环障碍(AMD)模型,采用活体微循环法观察肠系膜微循环细动,静脉血流速度(ABFV、VBFV),血流状态(BFS),血管口径(AD、VD)的变化。结果Asp2.5、5mg·kg-1、Ver0.3、0.6mg·kg-1,Asp+Ver(1+0.15)、(2.5 +0.3)mg ·kg -1iv可使ABFV增大各为11.1 %、31.3%、18.7%、19.5%、26.5%、37.3% ;VBFV则为12.5 %、25.7%、12.5 %、13.7%、30 %、34.7%,BFS改善 ;AD增大4.3 %、17.9 %、31.5%、35%、20%、38.1% ;VD则为2.2%、4.2 %、25 %、31.5 %、5.8 %、23.5% ;CN增多 ;Asp+Ver可明显逆转AMD。结论Asp 增快ABFV、VBFV作用优于Ver,而Ver扩张AD、VD作用强于Asp,两者合用呈协同效应。Aim To study the effects of aspirin (Asp) and verapamil (Ver)alone or in combination on mesenteric microcirculation of rats.Methods Acute microcirculation disturbance (AMD) was produced by highmolecular weight dextran (Mr 480,000)360 mg·kg-1 iv. Arteriol and venul blood flow velocity and diameter (ABFV,VBFV,AD,VD)and blood flow state(BFS) were observed by intravital microcirculation method. Results Asp 2.5,5 mg·kg-1,Ver 0.3,0.6 mg·kg-1,Asp+ Ver(1+0.15),(2.5+0.3) mg·kg-1 iv significant increase ABFV by 11.1%,31.3%,18.7%,19.5%,26.5%,37.3%,VBFV by 12.5%, 5.7%,2.5%,3.7%,30%,34.7%,AD by 4.3%,17.9%,31.5%, 35%,20%,38.1% and VD by 2.2%,4.2%, 25%, 31.5%,5.8%,23.5% espectively,and got a raise in the number of capillaries and a marked improvement of BFS.Asp+Ver(1+0.15,2.5+0.3) mg ·kg-1 iv could reverse AMD.Conclusion Asp is superior to Ver in the increase of BFV,but Ver is superior to Asp in expansion of blood vessel.Asp in combination with Ver produces marked synergistic action and protection againist AMD.

关 键 词：阿司匹林 维拉帕米 联合药物疗法 微循环 血流速度 

分 类 号：R969.2[医药卫生—药理学]