螺旋藻多糖对环磷酰胺所致小鼠骨髓抑制的实验研究  

Polysaccharide of spirulina on the prophylaxis and treatment of myelosuppression of mice caused by cyclophosphamide

作　　者：王德俊[1] 盛树青[1] 李瑞琴[1] 孙云[1] 张洪泉[1] 

机构地区：[1]扬州大学医学院,扬州225001

出　　处：《中国临床药理学与治疗学》2001年第1期46-48,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的研究螺旋藻多糖对小鼠骨髓造血功能的增强作用。方法将小鼠分成4组 :对照组、环磷酰胺模型组、螺旋藻多糖30mg·kg-1、螺旋藻多糖60mg·kg-1。模型组、螺旋藻多糖组腹腔注射环磷酰胺造模。同时螺旋藻多糖组灌胃螺旋藻多糖,对照组、模型组灌胃生理盐水。结果螺旋藻多糖在30、60mg·kg-1 剂量下 ,对环磷酰胺所致小鼠外周血象、骨髓有核细胞均有改善 (P<0.01)。对骨髓细胞微核增加有明显的拮抗作用 (P<0.05)。螺旋藻多糖组小鼠骨髓细胞染色体畸变率较模型组显著降低 ,其抑制率分别为51.2%、61.5 %。结论螺旋藻多糖可抑制环磷酰胺诱发的小鼠造血功能损伤。Aim The effect of polysaccharide of spirulina on mouse myelosuppression induced by cyclophosphamide was studied.Methods Mice in the model, treatment groups Ⅰand Ⅱwere given cyclophosphamide (ip 100 mg·kg-1) for there days.At the same time mice in the treatment groups Ⅰand Ⅱ were given ig spirulin 30 mg·kg-1 and 60 mg·kg-1 for ten days, while mice in the control group and model group were given ip 20 mg·kg-1 of NS.Peripheral blood and marrow cytometry, micromcelsus and chromosome aberration were analyed.Results In the dosages of 30 and 60 mg·kg-1 polysaccharide of spirulina,the polysaccharide of spirulina had perfect action on the perihemateikon and the function of bone hematoplast induced by cyclophosphamide (P<0.01) and antagonistic action on increase of bone cell micronuclsus(P<0.05);The ratio of chromosome aberration in the treated group was lower compared with that in the model group. The inhibitory ratio was 51.2% and 62.5% in the treated groups Ⅰand Ⅱ.Conclusion Polysaccharide of spirulina can perfect the hematoplast function of mice injured by cyclophosphamide.

关 键 词：螺旋藻多糖 骨髓抑制 环磷酰胺 微核染色体畸变 

分 类 号：R969.2[医药卫生—药理学]