国产阿昔洛韦咀嚼片人体生物等效性研究  

Study on bioavailability of domestic acyclovir chewable tablets

作　　者：王少华[1] 于宝东[1] 初晓[1] 石杰[1] 于进彩[1] 赵美玲[1] 

机构地区：[1]青岛市立医院,青岛266011

出　　处：《中国临床药理学与治疗学》2001年第1期51-53,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的比较国产阿昔洛韦咀嚼片与片剂的人体相对生物利用度。方法8名健康受试者进行随机交叉试验设计 ,分别先后单次口服800mg阿昔洛韦片剂或咀嚼片 ,采用高效液相色谱法测定血浆中阿昔洛韦浓度。结果咀嚼片与参比片剂的AUC0～t 分别为4.19和4.00μg·h·ml-1 ,相对生物利用度为 (105.8±13.1 ) %。Aim To compare the relative bioavailabilities of domestic acyclovir chewable tablets and normal tablets.Methods A single oral dose of 800 mg acyclovir chewable tablets or normal tablets was given to 8 volunteers respectively in a randomized,cross_over study,acyclovir serum concentration was determined by high performance liquid chromatography.Results The AUC of chewable and normal tablets was respectively 0.42 and 0.40 μg·ml·h-1,and the relative bioavailability of acyclovir chewable tablets was (105.8±13.1) %. Conclusion The chewable tablets and reference tablets is bioequivalent in AUC.

关 键 词：阿昔洛韦 生物利用度 高效液相色谱法 生物等效性 

分 类 号：R969.4[医药卫生—药理学] R978.7[医药卫生—药学]